Interleukin – 17 and Interleukin‑10 as Inflammatory and Prevention Biomarkers in Periimplant Diseases

Abstract

Background: Periimplant diseases are inflammatory diseases. Thus, the level of preinflammatory cytokines which has important role in the inflammation processes can consider as biomchemical markers for early diagnosis and prevention of periimplant diseases. The aim of this study was to determine and compare the level of interleukin (IL)‑17 and IL‑10 in patients with periimplant mucositis and periimplantitis.

Methods: This case‑‑control study was conducted on 51 patients with implants
which were loaded at least 1 year previously, 17 patients with periimplant mucositis, 17 patients with periimplantitis, and 17 individuals with healthy implants. After clinical examination, gingival crevicular fluid sampling was carried out by paper point number 25 for 4 min and the mean value of IL‑17, IL‑10 in samples was measured using enzyme linked immunosorbent assay (ELISA), least square differences (LSD) reader in laboratory. The data was analyzed using statistical software SPSS 22. Quantitative analysis was done using One‑way analysis of variance (ANOVA) test and LSD past  test.

Results: The results of analysis showed that there was a significant difference in the mean value of IL‑17 and IL‑10 between the three study groups (P < 0.001). Individuals with healthy implants showed a significant lower level of IL‑17 than patients with periimplantitis (P = 0.001) and for patients with periimplantitis,
the level of IL‑17 was significantly lower than that of patients with periimplant mucositis (P < 0.001) and IL‑10 level was significantly lower in mucositis than periimplantitis (P < 0.001).

Conclusions: The level of IL‑17 and IL‑10 increased in patients with periimplant compared to individuals with healthy periimplant tissues and the results showed that the highest concentrations of IL‑17 and IL‑10 were observed in patients with periimplant mucositis and periimplantitis, respectively.

Keywords: Interleukin‑10, interleukin‑17, mucositis, periimplantitis