Free Radical Production in the Smoking of E‑Cigarettes and their Possible Effects in Human Health

Roberto Menicagli, Ortensio Marotta, Roberta Serra


Background: The increase in smoking e‑cigarettes with nicotine or only flavoring compounds requires a deep study on consequences on human health. This research aims to study the possible process, to form free radicals or the nuclei’s damages with consequent micronuclei’s formation.

Methods: The study analyzed three groups: the first one that uses e‑cigarettes with
nicotine, (e‑nicotine), the second flavoured liquid (e‑vapor) and third the not‑smoking group. We determinated the salivary malondialdehyde (MDA), the total salivary mucins (SM). and in buccal smear cells the micronuclei (MN). We statistically analyzed the results with the Mann‑Whitney U Test Calculator.

Results: Smoking e‑cigarettes e‑nicotine or e‑vapor produced a great and significative amount of MDA vs control group: p ≤ 0.05. Only those smoking e‑nicotine, have a highest and statically significant amount of salivary mucins vs control group: P value 00496. In both smokers groups, the mean of MN scores has a significant difference vs control group P ≤ 0.05.

Conclusions: This study shows the possible damages of the nuclei, but the increase of radicals, oral mucins and MN needs more researches.

Keywords: Electronic nicotine delivery systems, free radicals, neoplasm

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