Ambient Temperature Interferes with COVID‑19

Manouchehr Ahmadi Hedayati


Dear Editor,
Angiotensin‑converting enzyme 2 (ACE2) is a blood pressure regulating enzyme that attaches to the outer surface in cells of the lungs, arteries, kidney, heart, and intestines. In addition to blood pressure regulating, ACE2 is involved in the pathophysiological processes by converting angiotensin isozymes during cell injury. ACE2 converts angiotensin II to angiotensin‑(1‑7).


Ambient Temperature; Interfere; COVID‑19

Full Text:



Imai Y, Kuba K, Penninger JM. The discovery of

angiotensin‑converting enzyme 2 and its role in acute lung injury

in mice. Exp Physiol 2008;93:543‑8.

Batlle D, Jose Soler M, Ye M. ACE2 and diabetes: ACE of

ACEs? Diabetes 2010;59:2994‑6.

Karpe PA, Tikoo K. Heat shock prevents insulin resistance–

induced vascular complications by Augmenting angiotensin‑(1‑7)

signaling. Diabetes 2014;63:1124‑39.

Wan Y, Shang J, Graham R, Baric RS, Li F. Receptor recognition

by novel coronavirus from Wuhan: An analysis based on

decade‑long structural studies of SARS. J Virol 2020. doi:


Mayengbam P, Tolenkhomba TC, Upadhyay RC. Expression of

heat‑shock protein 72 mRNA in relation to heart rate variability of Sahiwal and Karan‑Fries in different temperature‑humidity

indices. Vet World 2016;9:1051‑5.

Rajapaksha IG, Gunarathne LS, Asadi K, Cunningham SC,

Sharland A, Alexander IE, et al. Liver‑targeted angiotensin

converting enzyme 2 therapy inhibits chronic biliary fibrosis in

multiple drug‑resistant gene 2‑knockout mice. Hepatol Commun


Molteni CG, Principi N, Esposito S. Reactive oxygen and

nitrogen species during viral infections. Free Rad Res