Effects of Coenzyme Q10 Supplementation on Anthropometric Indices in Adults: A Systematic Review and Meta‑Analysis of Randomized Controlled Trials

Abed Ghavami, Hamed Mohammadi, Amir Hadi, Rahele Ziaei, Elyas Nattagh-Eshtivani, Mohammad Veysi Sheykhrobat, Gholamreza Askari

Abstract


Background: Obesity is related to increase in the incidence of morbidity and mortality. Previous studies have led to conflicting results regarding the effect of coenzyme Q10 (CoQ10) supplementation on anthropometric indices. This study aimed to evaluate the efficacy of CoQ10 supplementation on body weight, body mass index (BMI), and waist circumference (WC) through a systematic review and meta‑analysis of randomized controlled trials (RCTs). Methods: PubMed, Scopus, Web of Science, and Cochrane Library as well as the reference lists of the identified relevant RCTs were searched up to March 2019, and weighted mean differences (WMDs) were pooled by using the random‑effects model. Results: Twenty RCTs (976 participants) were eligible to be included in the systematic review. The meta‑analysis revealed that CoQ10 supplementation had no effect on body weight (WMD = −0.04 kg; 95% confidence interval [CI]: −1.96, 1.6; I2 = 0.0%), BMI (WMD = −0.06 kg/m2 ; 95% CI: −0.54, 0.42; I2 = 0.0%), and WC (WMD = 0.79 cm; 95% CI: −2.83, 0.04; I2 = 0.0%). Conclusions: CoQ10 supplementation might not improve anthropometric indices. Future well‑designed trials are still needed to confirm these results.

Keywords


Body mass index; body weight; CoQ10; meta-analysis; ubiquinone; waist circumference

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References


Abarca‑Gómez L, Abdeen ZA, Hamid ZA, Abu‑Rmeileh NM,

Acosta‑Cazares B, Acuin C, et al. Worldwide trends in body‑mass

index, underweight, overweight, and obesity from 1975 to 2016:

A pooled analysis of 2416 population‑based measurement

studies in 128 9 million children, adolescents, and adults. Lancet

;390:2627‑42.

Bell JA, Kivimaki M, Hamer M. Metabolically healthy obesity

and risk of incident type 2 diabetes: A meta‑analysis of

prospective cohort studies. Obes Rev 2014;15:504‑15.

Bastien M, Poirier P, Lemieux I, Després JP. Overview of

epidemiology and contribution of obesity to cardiovascular

disease. Prog Cardiovasc Dis 2014;56:369‑81.

Avgerinos KI, Spyrou N, Mantzoros CS, Dalamaga M.

Obesity and cancer risk: Emerging biological mechanisms and

perspectives. Metabolism 2018;92:121‑35.

Tremmel M, Gerdtham UG, Nilsson PM, Saha S. Economic

burden of obesity: A systematic literature review. Int J Environ

Res Public Health 2017;14:E435.

Morrison KM, Shin S, Tarnopolsky M, Taylor VH. Association

of depression & health related quality of life with body

composition in children and youth with obesity. J Affect Disord

;172:18‑23.

Soeliman FA, Azadbakht L. Weight loss maintenance: A review

on dietary related strategies. J Res Med Sci 2014;19:268‑75.

Saltiel AR. New therapeutic approaches for the treatment of

obesity. Sci Transl Med 2016;8:323rv2.

Srivastava G, Apovian CM. Current pharmacotherapy for obesity.

Nat Rev Endocrinol 2018;14:12‑4.

Tabrizi R, Akbari M, Sharifi N, Lankarani KB, Moosazadeh M,

Kolahdooz F, et al. The effects of coenzyme Q10 supplementation

on blood pressures among patients with metabolic diseases: A

systematic review and meta‑analysis of randomized controlled

trials. High Blood Press Cardiovasc Prev 2018;25:41‑50.

Fallah M, Askari G, Soleimani A, Feizi A, Asemi Z. Clinical trial

of the effects of coenzyme q10 supplementation on biomarkers

of inflammation and oxidative stress in diabetic hemodialysis

patients. Int J Prev Med 2019;10:12.

Aslani Z, Shab‑Bidar S, Fatahi S, Djafarian K. Effect of

coenzyme Q10 supplementation on serum of high sensitivity

c‑reactive protein level in patients with cardiovascular diseases:

A systematic review and meta‑analysis of randomized controlled

trials. Int J Prev Med 2018;9:82.

Fan L, Feng Y, Chen GC, Qin LQ, Fu Cl, Chen LH. Effects of

coenzyme Q10 supplementation on inflammatory markers: A

systematic review and meta‑analysis of randomized controlled

trials. Pharmacol Res 2017;119:128‑36.

Sahebkar A, Simental‑Mendía LE, Stefanutti C, Pirro M.

Supplementation with coenzyme Q10 reduces plasma lipoprotein

(a) concentrations but not other lipid indices: A systematic

review and meta‑analysis. Pharmacol Res 2016;105:198‑209.

Alcázar‑Fabra M, Navas P, Brea‑Calvo G. Coenzyme Q

biosynthesis and its role in the respiratory chain structure.

Biochim Biophys Acta 2016;1857:1073‑8.

Shahriary A, Khakzadihe M, Panahi Y. Appraisement function of

coenzyme Q10 on body weight changes blood serum biochemical

parameters in resembling type 2 diabetic male rats. J Appl Pharm

Sci 2017;7:114‑9.

Yuk T, Kim Y, Yang J, Sung J, Jeong HS, Lee J. Nobiletin

inhibits hepatic lipogenesis via activation of AMP‑activated

protein kinase. Evid Based Complement Alternat Med

;2018:7420265.

Izadi A, Ebrahimi S, Shirazi S, Taghizadeh S, Parizad M,

Farzadi L, et al. Hormonal and metabolic effects of coenzyme

q10 and/or vitamin E in patients with polycystic ovary syndrome.

J Clin Endocrinol Metab 2018;104:319‑27.

Moazen M, Mazloom Z, Ahmadi A, Dabbaghmanesh M,

Roosta S. Effect of coenzyme Q10 on glycaemic control,

oxidative stress and adiponectin in type 2 diabetes. J Pak Med

Assoc 2015;65:404‑8.

Higgins JP, Altman DG, Gøtzsche PC, Jüni P, Moher D,

Oxman AD, et al. The Cochrane Collaboration’s tool for

assessing risk of bias in randomised trials. BMJ 2011;343:d5928.

Borenstein M, Hedges LV, Higgins JP, Rothstein HR. Introduction

to Meta‑Analysis. United States: John Wiley & Sons; 2011.

Abdollahzad H, Alipour B, Aghdashi MA, Jafarabadi MA.

Coenzyme Q10 supplementation in patients with rheumatoid

arthritis: Are there any effects on cardiovascular risk factors? Eur

J Integr Med 2015;7:534‑9.

Dai Y‑L, Luk T‑H, Yiu K‑H, Wang M, Yip PM, Lee SW,

et al. Reversal of mitochondrial dysfunction by coenzyme

Q10 supplement improves endothelial function in patients with

ischaemic left ventricular systolic dysfunction: A randomized

controlled trial. Atherosclerosis 2011;216:395‑401.

Eriksson J, Forsen T, Mortensen S, Rohde M. The effect

of coenzyme Q10 administration on metabolic control

in patients with type 2 diabetes mellitus. Biofactors

;9:315‑8.

Farsi F, Mohammadshahi M, Alavinejad P, Rezazadeh A, Zarei M,

Engali KA. Functions of coenzyme Q10 supplementation on

liver enzymes, markers of systemic inflammation, and adipokines

in patients affected by nonalcoholic fatty liver disease: A

double‑blind, placebo‑controlled, randomized clinical trial. J Am

Coll Nutr 2016;35:346‑53.

Gholami M, Rezvanfar MR, Delavar M, Abdollahi M,

Khosrowbeygi A. Effects of coenzyme Q10 supplementation

on serum values of gamma‑glutamyl transferase,

pseudocholinesterase, bilirubin, ferritin, and high‑sensitivity

c‑reactive protein in women with type 2 diabetes. Exp Clin

Endocrinol Diabetes 2018.

Henriksen J, Andersen CB, Hother‑Nielsen O, Vaag A,

Mortensen SA, Beck‑Nielsen H. Impact of ubiquinone

(coenzyme Q10) treatment on glycaemic control, insulin

requirement and well‑being in patients with Type 1 diabetes

mellitus. Diabet Med 1999;16:312‑8.

Mohseni M, Vafa M, Zarrati M, Shidfar F,

Hajimiresmail SJ, Forushani AR. Beneficial effects of coenzyme

Q10 supplementation on lipid profile and intereukin‑6 and

intercellular adhesion molecule‑1 reduction, preliminary results

of a double‑blind trial in acute myocardial infarction. Int J Prev

Med 2015;6:73.

Mori TA, Burke V, Puddey IB, Irish AB, Cowpland CA,

Beilin LJ, et al. The effects of ω3 fatty acids and coenzyme Q10

on blood pressure and heart rate in chronic kidney disease: A

randomized controlled trial. J Hypertens 2009;27:1863‑72.

Rahmani E, Jamilian M, Samimi M, Zarezade Mehrizi M,

Aghadavod E, Akbari E, et al. The effects of coenzyme Q10

supplementation on gene expression related to insulin, lipid

and inflammation in patients with polycystic ovary syndrome.

Gynecol Endocrinol 2018;34:217‑22.

Zhang P, Yang C, Guo H, Wang J, Lin S, Li H, et al.

Treatment of coenzyme Q10 for 24 weeks improves lipid and

glycemic profile in dyslipidemic individuals. J Clin Lipidol

;12:417‑27. e5.

Fallah M, Askari G, Soleimani A, Feizi A, Asemi Z. Clinical trial

of the effects of coenzyme Q10 supplementation on glycemic

control and markers of lipid profiles in diabetic hemodialysis

patients. Int Urol Nephrol 2018;50:2073‑9.

Gholnari T, Aghadavod E, Soleimani A, Hamidi GA,

Sharifi N, Asemi Z. The effects of coenzyme Q10

supplementation on glucose metabolism, lipid profiles,

inflammation, and oxidative stress in patients with diabetic

nephropathy: A randomized, double‑blind, placebo‑controlled

trial. J Am Coll Nutr 2018;37:188‑93.

Hosseinzadeh‑Attar M, Kolahdouz Mohammadi R,

Eshraghian M, Nakhjavani M, Khorrami E, Ebadi M, et al.

Reduction in asymmetric dimethylarginine plasma levels by

coenzyme Q10 supplementation in patients with type 2 diabetes

mellitus. Minerva Endocrinol 2015;40:259‑66.

Jafarvand E, Farhangi MA, Alipour B, Khoshbaten M. Effects

of coenzyme Q10 supplementation on the anthropometric

variables, lipid profiles and liver enzymes in patients with

non‑alcoholic fatty liver disease. Bangladesh J Pharmacol

;11:35‑42.

Nadjarzadeh A, Sadeghi M, Amirjannati N, Vafa M,

Motevalian S, Gohari M, et al. Coenzyme Q10 improves seminal

oxidative defense but does not affect on semen parameters

in idiopathic oligoasthenoteratozoospermia: A randomized

double‑blind, placebo controlled trial. J Endocrinol Invest

;34:e224‑8.

Raygan F, Rezavandi Z, Tehrani SD, Farrokhian A, Asemi Z. The

effects of coenzyme Q10 administration on glucose homeostasis

parameters, lipid profiles, biomarkers of inflammation and

oxidative stress in patients with metabolic syndrome. Eur J Nutr

;55:2357‑64.

Shojaei M, Djalali M, Khatami M, Siassi F, Eshraghian M.

Effects of carnitine and coenzyme Q10 on lipid profile and serum

levels of lipoprotein (a) in maintenance hemodialysis patients on

statin therapy. Iran J Kidney Dis 2011;5:114‑8.

Hodgson J, Watts G, Playford D, Burke V, Croft K. Coenzyme

Q 10 improves blood pressure and glycaemic control: A

controlled trial in subjects with type 2 diabetes. Eur J Clin Nutr

;56:1137‑42.

Kumar S, Kelly AS, editors. Review of childhood obesity: From

epidemiology, etiology, and comorbidities to clinical assessment

and treatment. Mayo Clin Proc 2017;92:251‑65.

Mazidi M, Kengne AP, Banach M; Lipid, Lipid and Blood

Pressure Meta‑analysis Collaboration Group. Effects of

coenzyme Q10 supplementation on plasma C‑reactive protein

concentrations: A systematic review and meta‑analysis of

randomized controlled trials. Pharmacol Res 2018;128:130‑6.

Zhai J, Bo Y, Lu Y, Liu C, Zhang L. Effects of coenzyme Q10 on

markers of inflammation: A systematic review and meta‑analysis.

PLoS One 2017;12:e0170172.

Sharifi N, Tabrizi R, Moosazadeh M, Mirhosseini N,

Lankarani KB, Akbari M, et al. The effects of coenzyme Q10

supplementation on lipid profiles among patients with metabolic

diseases: A systematic review and meta‑analysis of randomized

controlled trials. Curr Pharm Des 2018;24:2729‑42.

Alam MA, Rahman MM. Mitochondrial dysfunction in

obesity: Potential benefit and mechanism of Co‑enzyme Q10

supplementation in metabolic syndrome. J Diabetes Metab

Disord 2014;13:60.

Carpéné C, Iffiú‑Soltész Z. Monoaminergic systems

and anti‑obesity drug discovery: Chronic administration

of sympathicomimetic amines, re‑uptake inhibitors, or

amine oxidase inhibitors. Anti‑Obesity Drug Discov Dev

;1:114‑30.

Xu Z, Huo J, Ding X, Yang M, Li L, Dai J, et al. Coenzyme

Q10 improves lipid metabolism and ameliorates obesity

by regulating CaMKII‑mediated PDE4 inhibition. Sci Rep

;7:8253.

Lee SK, Lee JO, Kim JH, Kim N, You GY, Moon JW, et al.

Coenzyme Q10 increases the fatty acid oxidation through

AMPK‑mediated PPARα induction in 3T3‑L1 preadipocytes.

Cell Signall 2012;24:2329‑36.

Choi Y, Kim Y, Ham H, Park Y, Jeong H‑S, Lee J. Nobiletin

suppresses adipogenesis by regulating the expression

of adipogenic transcription factors and the activation of

AMP‑activated protein kinase (AMPK). J Agric Food Chem

;59:12843‑9.

Vingtdeux V, Chandakkar P, Zhao H, Davies P,

Marambaud P. Small‑molecule activators of AMP‑activated

protein kinase (AMPK), RSVA314 and RSVA405, inhibit

adipogenesis. Mol Med 2011;17:1022‑30.

Zarei P, Rezvanfar MR, Ansarihadipour H, Delavar M,

Abdollahi M, Khosrowbeygi A. Effects of coenzyme Q10

supplementation on the serum levels of amylase, adenosine

deaminase, catalase, and total antioxidant capacity in women

with type 2 diabetes mellitus: A randomized, double‑blind

placebo‑controlled trial. J Res Med Sci 2018;23:91.

Hathcock JN, Shao A. Risk assessment for coenzyme Q10

(Ubiquinone). Regul Toxicol Pharmacol 2006;45:282‑8.

Jakicic JM. The role of physical activity in prevention and

treatment of body weight gain in adults. J Nutr 2002;132:3826S‑9S.

Rolls BJ, Drewnowski A, Ledikwe JH. Changing the energy

density of the diet as a strategy for weight management. J Am

Diet Assoc 2005;105:98‑103.

Chiolero A, Faeh D, Paccaud F, Cornuz J. Consequences of

smoking for body weight, body fat distribution, and insulin

resistance. Am J Clin Nutr 2008;87:801‑9.