Preventive Role of Cannabinoids Derivate against Methylphenidate‑Induced Oxidative Stress and Inflammation: The Hypothetical Function of Keap1/Nrf2/ARE Signaling and Proposal of a Treatment Strategy for Neurodegeneration

Afrah Sepehr, Fereshteh Taheri, Niyoosha Kandezi, Majid Motaghinejad, Sepideh Safari, Nilofar Mohammadi


Hypothesis Chronic methylphenidate abuse or administration causes oxidative stress, inflammation, and mitochondrial dysfunction in brain cells that require therapeutic approaches to inhibit neurotoxicity and neurodegeneration of these types.[1,2] Nonetheless, the function of methylphenidate in the induction of neurodegeneration or neuroprotection is uncertain, but most of the data support the function of methylphenidate in neurodegeneration.


Cannabinoids; Methylphenidate‑Induced; Oxidative Stress; Keap1/Nrf2/ARE; Neurodegeneration

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