A New Use for an Old Medicine: Dextromethorphan to Prevent Postoperative Sore Throat

Talisa M. Fernandes, Gauri R. Gangakhedkar


To the Editor, Postoperative sore throat (POST) is a well‑recognised complication after general anaesthesia (Incidence: 21–65%). POST is caused by trauma after airway instrumentation, leading to aseptic inflammation with congestion, oedema of pharyngolaryngeal mucosa, and raised biochemical markers, especially interleukin‑6.


Old Medicine; Dextromethorphan; Postoperative Sore Throat

Full Text:



Ahuja V, Mitra S, Sarna R. Nebulized ketamine decreases

incidence and severity of post‑operative sore throat. Indian J

Anaesth 2015;59:37‑42.

Vasileiou PV, Chalkias A, Brozou V, Papageorgiou‑Brousta M,

Kaparos G, Koutsovasilis A, et al. Interleukin‑6 as a marker of

inflammation secondary to endotracheal intubation in pediatric

patients. Inflammation 2013;36:1533‑8.

El‑Boghdadly K, Bailey CR, Wiles MD. Postoperative sore

throat: A systematic review. Anaesthesia 2016;71:706‑17.

King MR, Ladha KS, Gelineau AM, Anderson TA. Perioperative

dextromethorphan as an adjunct for postoperative pain:

A meta‑analysis of randomized controlled trials. Anesthesiology


National Center for Biotechnology Information. PubChem

Database. Dextromethorphan, CID=5360696. Available from:


[Last accessed on 2020 Jan 06].