Dietary Total Antioxidant Capacity and Risk of Gall Stone: A Case‑Control Study

Saeede Saadati, Ammar Salehi-sahlabadi, Fatemeh Hosseini-Oskouiee, Vahideh Aghamohammadi, Mortaza Ramezani, Behzad Askari, Alireza Sayyah, Amir Sadeghi, Azita Hekmatdoost


Background: Since the relation between dietary total antioxidant capacity (DTAC) and the occurrence of gallstone disease (GSD) remains unclear, we conducted, for the first time, a case‑control study to clarify this association in the Iranian population. Methods: In the present case‑control study, convenience Sampling was performed. A total of 600 participants (300 case and 300 control) were included. Anthropometric, demographic, physical activity, and nutrient intakes data were obtained from each subject. DTAC was calculated using the US Department of Agriculture’s database. The odds ratio (OR) and 95% confidence intervals were assessed using unconditional logistic regression. Results: The participants in the highest quartile of DTAC had a significantly lower OR for gallstone than the lowest quartile, which remained significant after further adjustment for age, sex, and education (model 2: OR, 0.34; 95% CI, 0.16–0.71). In addition, after adjustment for age, sex, education, BMI, physical activity, and energy, the results revealed that participants with the highest quartile of DTAC had 71% lower odds of gallstone than those with the lowest quartile (model 3: OR, 0.29; 95% CI, 0.11–0.78). Conclusions: The results of the present study demonstrated that the DTAC had an inverse association with GSD incident. However, interventional approaches are needed to confirm the relation between DTAC and GSD prevention


Free radicals; gallstone; oxidative stress; total antioxidant capacity

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