Psychometric Properties of the Persian Version of the Multiple Sclerosis Work Difficulties Questionnaire (MSWDQ) Questionnaire

Omid Mirmosayyeb, Vahid Shaygannejad, Soroush Najdaghi, Mahsa Ghajarzadeh


Background: Patients with multiple sclerosis (MS) suffer from a wide range of psychological and physical problems. Employment status is a crucial issue for patients with MS as unemployment while it is not completely evaluated in patients with MS. Objectives: To assess psychometrical properties of the Persian version of the Multiple Sclerosis Work Difficulties Questionnaire (MSWDQ). Methods: One hundred and sixty patients were enrolled. They were asked to fill valid and reliable Persian version of the Fatigue Severity Scale (FSS), social support scale, and Short Form Health Survey (SF‑36) and translated version of the MSWDQ questionnaire. Twenty cases filed the questionnaire two weeks later to assess reliability. The intra‑class correlation coefficient (ICC), Cronbach’s alpha, correlation coefficients were used. Results: Mean age and mean duration of the disease were 36.8 ± 9.1, and 7.5 ± 5.1, respectively. The Cronbach alpha for psychological/cognitive barriers subscale was 0.87, for Physical barriers was 0.83 and for external barriers was 0.86. The Cronbach α for the whole questionnaire was 0.89. There was a significant positive correlation between FSS and MSWDQ score, and a significant correlation with SF‑36 and social support. The ICCs of all questions were acceptable. Conclusions: Persian version of MSWDQ questionnaire is a valid and reliable instrument for evaluating work‑related problems in patients with MS.


Iran; multiple sclerosis; Persian; work

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Ghajarzadeh M, Jalilian R, Eskandari G, Sahraian MA, Azimi A,

Mohammadifar M. Fatigue in multiple sclerosis: Relationship

with disease duration, physical disability, disease pattern, age

and sex. Acta Neurol Belg 2013;113:411‑4.

Ghajarzadeh M, Azizi S, Moghadasi AN, Sahraian MA, Azimi A,

Mohammadifar M, et al. Validity and reliability of the persian

version of the PERception de la scle’rose en plaques et de ses

pousse’es questionnaire evaluating multiple sclerosis‑related

quality of life. Int J Prev Med 2016;7:25.

Ghajarzadeh M, Jalilian R, Sahraian MA, Moghadasi AN,

Azimi A, Mohammadifar M, et al. Pain in patients with multiple

sclerosis. Maedica (Bucur) 2018;13:125‑30.

Busche K, Fisk J, Murray T, Metz L. Short term predictors of

unemployment in multiple sclerosis patients. Can J Neurol Sci


Schiavolin S, Leonardi M, Giovannetti AM, Antozzi C,

Brambilla L, Confalonieri P, et al. Factors related to difficulties

with employment in patients with multiple sclerosis: A review of

–2011 literature. Int J Rehabil Res 2013;36:105‑11.

Schiavolin S, Giovannetti AM, Leonardi M, Brenna G,

Brambilla L, Confalonieri P, et al. Multiple sclerosis

questionnaire for job difficulties (MSQ‑Job): Definition of the

cut‑off score. Neurol Sci 2016;37:777‑80.

Simmons RD. Life issues in multiple sclerosis. Nat Rev Neurol


Honan CA, Brown RF, Hine DW, Vowels L, Wollin JA,

Simmons RD, et al. The multiple sclerosis work difficulties

questionnaire. Mult Scler 2012;18:871‑80.

Almasi‑Hashiani A, Sahraian MA, Eskandarieh S. Evidence of

an increased prevalence of multiple sclerosis: A population‑based

study of Tehran registry during 1999‑2018. BMC Neurol


Azimian M, Shahvarughi Farahani A, Dadkhah A, Fallahpour M,

Karimlu M. Fatigue severity scale: The psychometric properties

of the Persian‑version in patients with multiple sclerosis. Res J

Biol Sci 2009;4:974‑7.

Bagherian‑Sararoudi R, Hajian A, Ehsan HB, Sarafraz MR,

Zimet GD. Psychometric properties of the Persian version of the

multidimensional scale of perceived social support in Iran. Int J

Prev Med 2013;4:1277‑81.

Montazeri A, Goshtasebi A, Vahdaninia M, Gandek B. The Short

Form Health Survey (SF‑36): Translation and validation study of

the Iranian version. Qual Life Res 2005;14:875‑82.

Kahraman T, Özdoğar AT, Honan CA, Ertekin Ö, Özakbaş S.

The multiple sclerosis work difficulties questionnaire: Translation

and cross‑cultural adaptation to Turkish and assessment of

validity and reliability. Disabil Rehabil 2019;41:2556‑62.

Ghajarzadeh M, Sahraian MA, Fateh R, Daneshmand A. Fatigue,

depression and sleep disturbances in Iranian patients with

multiple sclerosis. Acta Med Iran 2012;50:244‑9.

Schwartz C, Frohner R. Contribution of demographic, medical,

and social support variables in predicting the mental health

dimension of quality of life among people with multiple

sclerosis. Health Soc Work 2005;30:203‑12.

Krokavcova M, van Dijk JP, Nagyova I, Rosenberger J,

Gavelova M, Middel B, et al. Social support as a predictor of

perceived health status in patients with multiple sclerosis. Patient

Educ Couns 2008;73:159‑65.

Lobentanz I, Asenbaum S, Vass K, Sauter C, Klösch G,

Kollegger H, et al. Factors influencing quality of life in multiple

sclerosis patients: Disability, depressive mood, fatigue and sleep

quality. Acta Neurol Scand 2004;110:6‑13.