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Investigation of the Effects of Maternal Nutrition during Pregnancy on Cognitive Functions of Toddlers: A Systematic Review
Abstract
Background: Growing the human brain requires all necessary nutrients to form and maintain, so the development of cognitive functions of infants and children depends on adequate nutrition. Children whose mothers had inadequate nutrition are at high risk for cognitive dysfunction. The objective of the present study was to review the studies conducted on “the relationship between nutrient intake during pregnancy and the development of cognitive functions in toddlers”. The present study was conducted by systematic review method using PRISMA checklist items. Methods: To conduct this study, the keywords “maternal nutrition”, “pregnancy diet”, “pregnancy supplement”, “IQ”, “intelligence quotient”, “neurodevelopment”, “cognitive function”, “toddler”, “early years” and “infant” were searched based on the Mesh database in scientific databases including Scopus, SID, Google Scholar, PubMed, and Science Direct to find articles related to the effect of nutrition during pregnancy on the development of the cognitive function of toddlers and its components in Persian and English. Finally, 17 articles were selected for review in this study. Results: The results showed that taking a supplement of iron, saturated fatty acids, vitamins B and D, and folic acid improved the cognitive functions of toddlers. On the other hand, taking supplements containing iodine and zinc had no significant effect on the development of cognitive functions. Diets containing seafood during pregnancy had a beneficial effect on the cognitive functions of children. Conclusions: The study results highlighted the importance of adequate nutrition during pregnancy and showed that maternal nutrition played an important role in the development of cognitive functions of toddlers.
International Journal of Preventive Medicine 15():15, March 2024. | DOI: 10.4103/ijpvm.ijpvm_124_22
Corresponding Author: Dr. Elham Aghaie
E‑mail:elhamaghaie89@gmail.com
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Nyaradi A, Li J, Hickling S, Foster J, Oddy WH. The role
of nutrition in children’s neurocognitive development, from
pregnancy through childhood. Front Hum Neurosci 2013;7:97.
Engle PL, Fernández PD. INCAP studies of malnutrition and
cognitive behavior. Food Nutr Bull 2010;31:83-94.
de Souza AS, Fernandes FS, Tavares do Carmo MDG. Effects of
maternal malnutrition and postnatal nutritional rehabilitation on
brain fatty acids, learning, and memory. Nutr Rev 2011;69:132-44.
Zimmermann MB. The role of iodine in human growth and
development. Semin Cell Dev Biol 2011;22:645-52.
Hibbeln JR, Spiller P, Brenna JT, Golding J, Holub BJ,
Harris WS, et al. Relationships between seafood consumption
during pregnancy and childhood and neurocognitive
development: Two systematic reviews. Prostaglandins Leukot
Essent Fatty Acids 2019;151:14-36.
Arija V, Canals J. Effect of maternal nutrition on cognitive
function of children. Nutrients 2021;13:1644.
Ghosh SS, Kakunoori S, Augustinack J, Nieto Castanon A,
Kovelman I, Gaab N, et al. Evaluating the validity of
volume based and surface based brain image registration for
developmental cognitive neuroscience studies in children 4 to 11
years of age. Neuroimage 2010;53:85-93.
Lillycrop KA, Burdge GC. The effect of nutrition during early
life on the epigenetic regulation of transcription and implications
for human diseases. J Nutrigenet Nutrigenomics 2011;4:248-60.
Penhune VB. Sensitive periods in human development: Evidence
from musical training. Cortex 2011;47:1126-37.
Valent F, Mariuz M, Bin M, Mazej D, Tognin V, Tratnik J,
et al. Associations of prenatal mercury exposure from maternal
fish consumption and polyunsaturated fatty acids with child
neurodevelopment: A prospective cohort study in Italy. J
Epidemiol 2013;23:360-70.
Julvez J, Méndez M, Fernandez Barres S, Romaguera D,
Vioque J, Llop S, et al. Maternal consumption of seafood
in pregnancy and child neuropsychological development: A
longitudinal study based on a population with high consumption
levels. Am J Epidemiol 2016;183:169-82.
Lv S, Qin R, Jiang Y, Lv H, Lu Q, Tao S, et al. Association
of maternal dietary patterns during gestation and offspring
neurodevelopment. Nutrients 2022;14:730.
Ramakrishnan U, Stinger A, DiGirolamo AM, Martorell R,
Neufeld LM, Rivera JA, et al. Prenatal docosahexaenoic acid
supplementation and offspring development at 18 months:
randomized controlled trial. PloS one 2015;10 :e0120065.
Makrides M, Gibson RA, McPhee AJ, Yelland L, Quinlivan J,
Ryan P. Effect of DHA supplementation during pregnancy on
maternal depression and neurodevelopment of young children: A
randomized controlled trial. JAMA 2010;304:1675-83.
Gould JF, Makrides M, Colombo J, Smithers LG. Randomized
controlled trial of maternal omega 3 long chain PUFA
supplementation during pregnancy and early childhood
development of attention, working memory, and inhibitory
control. Am J Clin Nutr 2014;99:851-9.
Keim SA, Boone KM, Klebanoff MA, Turner AN, Rausch J,
Nelin MA, et al. Effect of docosahexaenoic acid supplementation
vs placebo on developmental outcomes of toddlers born preterm:
A randomized clinical trial. JAMA Pediatr 2018;172:1126-34.
Khandelwal S, Kondal D, Chaudhry M, Patil K, Swamy MK,
Metgud D, et al. Effect of maternal docosahexaenoic acid (DHA)
supplementation on offspring neurodevelopment at 12 months in
India: A randomized controlled trial. Nutrients 2020;12:3041.
Morales E, Guxens M, Llop S, Rodriguez Bernal CL, Tardon A,
Riano I, et al. INMA Project. Circulating 25 hydroxyvitamin
D3 in pregnancy and infant neuropsychological development.
Pediatrics 2012;130:e913-20.
Brown RD, Langshaw MR, Uhr EJ, Gibson JN, Joshua DE. The
impact of mandatory fortification of flour with folic acid on the
blood folate levels of an Australian population. Medical journal
of Australia. 2011;194:65-7.
Thomas S, Thomas T, Bosch RJ, Ramthal A, Bellinger DC,
Kurpad AV, et al. Effect of maternal vitamin B12 supplementation
on cognitive outcomes in south Indian children: A randomized
controlled clinical trial. Matern Child Health J 2019;23:155-63.
Chatzi L, Papadopoulou E, Koutra K, Roumeliotaki T,
Georgiou V, Stratakis N, et al. Effect of high doses of folic acid
supplementation in early pregnancy on child neurodevelopment
at 18 months of age: The mother child cohort ‘Rhea’ study in
Crete, Greece. Public Health Nutr 2012;15:1728-36.
Chang S, Zeng L, Brouwer ID, Kok FJ, Yan H. Effect of iron
deficiency anemia in pregnancy on child mental development in
rural China. Pediatrics 2013;131:e755-63.
Velasco I, Carreira M, Santiago P, Muela JA, García Fuentes E, Sanchez Munoz B, et al. Effect of iodine prophylaxis during
pregnancy on neurocognitive development of children during the
first two years of life. J Clin Endocrinol Metab 2009;94:3234-41.
Murcia M, Rebagliato M, Iniguez C, Lopez Espinosa MJ,
Estarlich M, Plaza B, et al. Effect of iodine supplementation
during pregnancy on infant neurodevelopment at 1 year of age.
Am J Epidemiol 2011;173:804-12.
Rebagliato M, Murcia M, Álvarez Pedrerol M, Espada M,
Fernández Somoano A, Lertxundi N, et al. Iodine
supplementation during pregnancy and infant neuropsychological
development: INMA mother and child cohort study. Am J
Epidemiol 2013;177:944-53.
Zhou SJ, Condo D, Ryan P, Skeaff SA, Howell S, Anderson PJ,
et al. Association between maternal iodine intake in pregnancy
and childhood neurodevelopment at age 18 months. Am J
Epidemiol 2019;188:332-8.
Marti A, Fortique F. Omega 3 fatty acids and cognitive decline:
A systematic review. Nutr Hosp 2019;36:939-49.
Zeisel SH. Choline: Critical role during fetal development and
dietary requirements in adults. Annu Rev Nutr 2009;26:229-50.
Zhang XM, Huang GW, Tian ZH, Ren DL, Wilson JX. Folate
stimulates ERK1/2 phosphorylation and cell proliferation in fetal
neural stem cells. Nutr Neurosci 2009;12:226-32.
Dror DK, Allen LH. Effect of vitamin B12 deficiency on
neurodevelopment in infants: Current knowledge and possible
mechanisms. Nutr Rev 2008;66:250-5.
Darling AL, Rayman MP, Steer CD, Golding J, Lanham New
SA, Bath SC. Association between maternal vitamin D status
in pregnancy and neurodevelopmental outcomes in childhood.
Results from the Avon Longitudinal Study of Parents and
Children (ALSPAC). Br J Nutr 2017;117:1682-92.
Ali A, Cui X, Eyles D. Developmental vitamin D deficiency and
autism: Putative pathogenic mechanisms. J Steroid Biochem Mol
Biol 2018;175:108-18.
Garcia-Serna AM, Morales E. Neurodevelopmental effects of
prenatal vitamin D in humans: systematic review and metaanalysis. Molecular psychiatry. 2020; 25:2468-81.
Patrick RP, Ames BN. Vitamin D and the omega-3 fatty acids
control serotonin synthesis and action, part 2: Relevance for
ADHD, bipolar disorder, schizophrenia, and impulsive behavior.
FASEB J 2015;29:2207-22.
Jayasinghe C, Polson R, van Woerden HC, Wilson P. The
effect of universal maternal antenatal iron supplementation on
neurodevelopment in offspring: A systematic review and meta
analysis. BMC Pediatr 2018;18:1-9.
Wechsler D. Wechsler intelligence scale for children-revised.
Psychological Corporation; 1974.
Zhou SJ, Gibson RA, Crowther CA, Baghurst P, Makrides M.
Effect of iron supplementation during pregnancy on the
intelligence quotient and behavior of children at 4 y of age:
Long term follow up of a randomized controlled trial. Am J Clin
Nutr 2006;83:1112-7.
Gallego G, Goodall S, Eastman CJ. Iodine deficiency in
Australia: Is iodine supplementation for pregnant and lactating
women warranted? Med J Aust 2010;192:461-3.
Qian M, Wang D, Watkins WE, Gebski V, Yan YQ, Li M, et al.
The effects of iodine on intelligence in children: A meta analysis of
studies conducted in China. Asia Pac J Clin Nutr 2005;14:32-42.
Ota E, Mori R, Middleton P, Tobe-Gai R, Mahomed K,
Miyazaki C, et al. Zinc supplementation for improving
pregnancy and infant outcome. Cochrane Database of Systematic
Reviews 2015(2).
Mousa A, Naqash A, Lim S. Macronutrient and micronutrient
intake during pregnancy: An overview of recent evidence.
Nutrients. 2019;11:443.
Jiménez Chillarón JC, Díaz R, Martínez D, Pentinat T, Ramón
Krauel M, Ribó S, et al. The role of nutrition on epigenetic
modifications and their implications on health. Biochimie
;94:2242-63.
Chaffee BW, King JC. Effect of zinc supplementation on
pregnancy and infant outcomes: a systematic review. Paediatric
and perinatal epidemiology. 2012;26:118-37.
Hamadani JD, Fuchs GJ, Osendarp SJ, Huda SN, GranthamMcGregor SM. Zinc supplementation during pregnancy and
effects on mental development and behaviour of infants: a
follow-up study. The Lancet 2002;360:290-4.