A Narrative Review of Herbal Remedies for Managing Hirsutism

Razieh Ghanbarian, Maryam Ranjbar, Mahmoud Babaeian, Mohammad Mazaheri

Abstract


Hirsutism is a condition that can have medical, social, and psychological implications, affecting 5% to 10% of women worldwide. Management options include cosmetic procedures and pharmacological interventions. However, medications used to treat hirsutism can have side effects, ranging from mild symptoms like nausea and headaches to more serious complications such as vascular clots, heart attacks, hepatotoxicity, osteoporosis, and effeminization of a male fetus. Therefore, this study aims to investigate the potential benefits of medicinal plants on hirsutism as a complementary approach, specifically whether they can be used as adjuvants to cosmetic procedures. Databases including Google Scholar, PubMed, Scopus, Embase, ISI, SID, and Mag Iran have been checked with related keywords from 2000 to 2023. Moreover, related articles were isolated. In total, ten trials were identified in the search. The results suggested that various herbs, including fennel, licorice, spearmint, saw palmetto, green tea, combination of Zingiber and neem, curcumin, and teupolioside have the potential as herbal remedies for hirsutism. However, further extensive well‑designed studies involving a large sample size on the most promising herbs are necessary to determine their efficacy.

 

International Journal of Preventive Medicine 15():17, March 2024. | DOI: 10.4103/ijpvm.ijpvm_62_23

Corresponding Author: Dr. Mohammad Mazaheri

E‑mail:mazaherimohammad@med.mui.ac.ir

You can also search for this author in: PubMed Google Scholar


Keywords


Herb; herbal medicine; herbal remedies; hirsutism; medicinal herb

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References


Tewary S, Davies R, Prakash A. Hirsutism. Obst Gynaecol

Reprod Med 2021;31. doi: 10.1016/j.ogrm. 2021.02.004

Escobar-Morreale HF. Diagnosis and management of hirsutism.

Ann N Y Acad Sci 2010;1205:166‑74.

Barrionuevo P, Nabhan M, Altayar O, Wang Z, Erwin PJ,

Asi N, et al. Treatment options for hirsutism: A systematic

review and network meta‑analysis. J Clin Endocrinol Metab

;103:1258‑64.

Bhat YJ, Bashir S, Nabi N, Hassan I. Laser treatment in hirsutism:

An update. Dermatol Pract Concept 2020;10:e2020048.

Pathania YS, Budania A, Rafi S, Kumar A. Psychosocial and

financial impact of facial hair among female patients of hirsutism:

A cross-sectional study. J Cosmet Dermatol 2023;22:1906‑10.

Cooper DB, Patel P, Mahdy H. Oral contraceptive pills. Treasure

Island (FL): StatPearls Publishing; 2023.

Soares Júnior JM, Guimarães DZ, Simões RdS, Veiga ECdA,

Roa CL, Sorpreso ICE, et al. Systematic review of finasteride effect

in women with hirsutism. Rev Assoc Méd Brasil 2021;67:1043‑9.

Lumachi F, Basso S. Medical treatment of hirsutism in women.

Curr Med Chem 2010;17:2530‑8.

Yuan H, Ma Q, Ye L, Piao G. The traditional medicine and

modern medicine from natural products. Molecules 2016;21:559.

Pan S‑Y, Litscher G, Gao S‑H, Zhou S‑F, Yu Z‑L, Chen H‑Q, et al.

Historical perspective of traditional indigenous medical practices:

The current renaissance and conservation of herbal resources.

Evid Based Complement Alternat Med 2014;2014:525340.

Javidnia K, Dastgheib L, Samani SM, Nasiri A. Antihirsutism

activity of fennel (fruits of Foeniculum vulgare) extract–A

double‑blind placebo controlled study. Phytomedicine

;10:455‑8.

Akha O, Rabiei K, Kashi Z, Bahar A, Zaeif‑Khorasani E,

Kosaryan M, et al. The effect of fennel (Foeniculum vulgare) gel

% in decreasing hair thickness in idiopathic mild to moderate

hirsutism, A randomized placebo controlled clinical trial. Caspian

J Intern Med 2014;5:26‑9.

Armanini D, Mattarello MJ, Fiore C, Bonanni G, Scaroni C,

Sartorato P, et al. Licorice reduces serum testosterone in healthy

women. Steroids 2004;69:763‑6.

Faghihi G, Iraji F, Abtahi‑Naeini B, Saffar B, Saffaei A,

Pourazizi M, et al. Complementary therapies for idiopathic

hirsutism: Topical licorice as promising option. Evid Based

Complement Alternat Med 2015;2015:659041.

Akdoğan M, Tamer MN, Cüre E, Cüre MC, Köroğlu BK,

Delibaş N. Effect of spearmint (Mentha spicata Labiatae) teas

on androgen levels in women with hirsutism. Phytother Res

;21:444‑7.

Grant P. Spearmint herbal tea has significant anti-androgen

effects inpolycystic ovarian syndrome. A randomized controlled

trial. Phytother Res 2010;24:186‑8.

Yousefi M, Barikbin B, Givrad S, Moravej H, Khoushnoudi R.

The effectiveness of the extract of serenoa repens (Saw Palmetto)

in idiopathic facial hirsutism (letter to editor). Iran J Dermatol

;12:139‑4.

Anjum F, Shameem I, Mubeen U. Efficacy of azadirachta

indica and zingiber officinale on hirsutism in polycystic ovarian

disease: A randomized controlled trial. Int J Innov Res Med

Sci (IJIRMS). 2018;3:1937‑45.

Moore D. Use of herbal remedies in polycystic ovarian

syndrome (PCOS) and hirsutism. Asian J Med Princ Clin Pract

;5:268-71.

Malvasi A, Tinelli A, Dellino M, Troiano G, Vinciguerra M,

Mina M. Curcumin and teupolioside attenuate signs and

symptoms severity associated to hirsutism in PCOS women:

A preliminary pilot study. Eur Rev Med Pharmacol Sci

;26:6187‑91.

Mahboubi M. Foeniculum vulgare as valuable plant in

management of women’s health. J Menopausal Med

;25:1‑14.

Rahimi R, Ardekani MRS. Medicinal properties of Foeniculum

vulgare Mill. in traditional Iranian medicine and modern

phytotherapy. Chin J Integr Med 2013;19:73‑9.

Niiyama S, Happle R, Hoffmann R. Influence of estrogens on

the androgen metabolism in different subunits of human hair

follicles. Eur J Dermatol 2001;11:195‑8.

Sabbadin C, Bordin L, Donà G, Manso J, Avruscio G,

Armanini D. Licorice: From pseudohyperaldosteronism to

therapeutic uses. Front Endocrinol 2019;10:484.

Tamir S, Eizenberg M, Somjen D, Izrael S, Vaya J. Estrogen‑like

activity of glabrene and other constituents isolated from licorice

root. J Steroid Biochem Mol Biol 2001;78:291‑8.

Yang R, Wang L‑Q, Yuan B‑C, Liu Y. The pharmacological

activities of licorice. Planta Med 2015;81:1654‑69.

Boukhebti H, Chaker AN, Belhadj H, Sahli F, Ramdhani M,

Laouer H, et al. Chemical composition and antibacterial activity

of Mentha pulegium L. and Mentha spicata L. essential oils. Der

Pharm Lett 2011;3:267‑75.

Kwon Y. Use of saw palmetto (Serenoa repens) extract

for benign prostatic hyperplasia. Food Sci Biotechnol

;28:1599‑606.

Evron E, Juhasz M, Babadjouni A, Mesinkovska NA. Natural

hair supplement: Friend or foe? Saw Palmetto, a systematic

review in alopecia. Skin Appendage Disord 2020;6:329‑37.

Mishra RK, Kumar A, Kumar A. Pharmacological activity of

Zingiber officinale. Int J Pharm Chem Sci 2012;1:1073‑8.

Zeenat F, Ravish MS, Ahmad W, Ahmad I. Therapeutic,

phytochemistry and pharmacology of Azadirachta indica:

A review. Int J Endocrinol 2018;2:20‑8.

Pazyar N, Feily A, Kazerouni A. Green tea in dermatology.

Skinmed 2012;10:352‑5.

Namazi MR, Feily A. Green tea extract: A novel addition to

the antihirsutism armamentarium? J Alternat Complement Med

;15:700‑1.

Zink A, Traidl-Hoffmann C. Green tea in dermatology–myths

and facts. J Dtsch Dermatol Ges 2015;13:768‑75.

Azizi A, Mumin NH, Shafqat N. Phytochemicals with anti

‑alpha‑reductase activity: A prospective for prostate cancer

treatment. F1000Research 2021;10:221.

Hiipakka RA, Zhang H‑Z, Dai W, Dai Q, Liao S. Structure–

activity relationships for inhibition of human 5α‑reductases by

polyphenols. Biochem Pharmacol 2002;63:1165‑76.

Srivilai J, Rabgay K, Khorana N, Waranuch N,

Nuengchamnong N, Wisuitiprot W, et al. Anti‑androgenic

curcumin analogues as steroid 5‑alpha reductase inhibitors. Med

Chem Res 2017;26:1550‑6.