Relation between Body Iron Status and Cardiovascular Risk Factors in Patients with Cardiovascular Disease

Mohammad Hassan Eftekhari, Hassan Mozaffari-Khosravi, Farzad Shidfar, Atefeh Zamani


Background: There is conflicting evidence regarding the relationship between iron stores and cardiovascular disease (CVD). The present study aimed to investigate the association between body iron indices and some cardiovascular risk factors.

Methods: In a case–control study conducted in the south of Shiraz, Iran, we determined ferritin, iron, total iron binding capacity (TIBC), metabolic risk factors, C‑reactive protein (CRP), and anthropometric measurements in 100 men aged 45 years and higher with newly diagnosed CVD and 100 adjusted controls without evidence for CVD.

Results: The mean of low density lipoprotein (LDL‑c), CRP, and ferritin concentrations were significantly higher in cases than controls, and high density lipoprotein (HDL‑c) was significantly lower in cases than controls. Pearson correlation coefficient between CRP and the other risk factors in case group showed that only ferritin, serum iron, waist circumference, and LDL‑c significantly correlated with CRP (r = 0.32 with P < 0.001, r = 0.29 with P < 0.05, r = 0.41 with P < 0.01, and r = 0.36 with P < 0.001, respectively).

Conclusions: This study indicated an association between a positive balance of body iron and CVD. Hence, caution should be exercised in administration of iron supplements to patients with CVD and in consumption of food rich in iron by them.

Keywords: C‑reactive protein, cardiovascular disease, ferritin

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