Effect of 50% Hydro-Ethanolic Leaf Extracts of Ruellia Tuberosa L. and Dipteracanthus Patulus (Jacq.) on Lipid Profile in Alloxan Induced Diabetic Rats

Abstract

Background: The study was undertaken to investigate the effect of 50% hydro ‑ethanolic leaf extracts of Ruellia tuberosa L. and Dipteracanthus patulus (Jacq.) on lipid profile in alloxan induced diabetic rats.

Method: In lipid profile the parameters studied were serum total cholesterol, phospholipids, triglycerides, HDL‑c, LDL‑c and VLDL‑c level. Extracts were orally administered daily for 30 days at a dosage of 250 and 500 mg/kg bodyweight to alloxan induced diabetic rats.

Results: The levels of phospholipids, triglycerides, LDL‑c and VLDL‑c were significantly (P < 0.05) reduced. The HDL‑c level was found to be increased in the treatment groups. Total cholesterol level was found to be significantly (P < 0.05) decreased at 500 mg/ kg bodyweight of both the plant extracts treated groups.

Conclusion: The results further suggests that the effect of plant extract treated groups was found to be lower in reducing the lipid levels in serum when compared to the drug (Glibenclamide 600 μg/kg body weight) treated group.

Keywords: Dipteracanthus patulus (Jacq.), lipid profile, Ruellia tuberosa L