<ArticleSet>
<Article>
<Journal>
<PublisherName></PublisherName>
<JournalTitle>International Journal of Preventive Medicine</JournalTitle>
<Issn>2008-7802</Issn>
<Volume>3</Volume>
<Issue>1</Issue>
<PubDate>
<Year>2011</Year>
<Month>07</Month>
<Day>16</Day>
</PubDate>
</Journal>
<ArticleTitle>The Effect of Statin Therapy in Stroke Outcome: A Double Blind Clinical Trial</ArticleTitle>
<FirstPage>160</FirstPage>
<LastPage>160</LastPage>
<Language>EN</Language>
<AuthorList>
<Author>
<FirstName>Mohammad</FirstName>
<LastName>Zare</LastName>
</Author>
<Author>
<FirstName>Mohammad</FirstName>
<LastName>Saadatnia</LastName>
<Affiliation>Associate Professor of Neurology, Isfahan Neurosciences Research Center, Isfahan University of Medical Science, Isfahan, Iran.. mosaadatnia@yahoo.com</Affiliation>
</Author>
<Author>
<FirstName>Seyed Ali</FirstName>
<LastName>Mousavi</LastName>
</Author>
<Author>
<FirstName>Kiandokht</FirstName>
<LastName>Keyhanian</LastName>
</Author>
<Author>
<FirstName>Vahid</FirstName>
<LastName>Davoudi</LastName>
</Author>
<Author>
<FirstName>Esmaeil</FirstName>
<LastName>Khanmohammadi</LastName>
</Author>
</AuthorList>
<History>
<PubDate>
<Year>2011</Year>
<Month>04</Month>
<Day>09</Day>
</PubDate>
<PubDate>
<Year>2011</Year>
<Month>07</Month>
<Day>14</Day>
</PubDate>
<PubDate>
<Year>2011</Year>
<Month>07</Month>
<Day>14</Day>
</PubDate>
</History>
<Abstract>Background: Through a clinical trial we evaluated statin therapy benefits over stroke outcome.Methods: All patients with moderate stroke in Middle Cerebral Artery (MCA) were registered during February&nbsp; 2006 to February&nbsp; 2008, in Al Zahra Hospital, Isfahan, Iran. Among 55&nbsp; patients who were enrolled in the present study, 25&nbsp; subjects received 20 mg lovastatin daily, for 90&nbsp; days after stroke attack (group 1) and 30 patients received no treatment (group 2). Patients were assessed at admission, 7 and 90&nbsp; days after stroke. National Institutes of&nbsp; Health Stroke Scale&nbsp; (NIHSS) score was recorded in the day 1 and 7 in the hospital with a questionnaire and BARTHEL index was estimated 90 days after stroke incidence by a telephone survey or in an outpatient visit. Data were analyzed by means of &chi;2 , &lsquo;t&rsquo; test and Independent &lsquo;t&rsquo; test.Results: NIHSS score measured in first day immediately after stroke attack and following 7 days, did not differ significantly in two groups. Moreover, BARTHEL index recorded within 90 days was not also different comparing group 1 and 2. After 90 days, no mortality was recorded in group&nbsp; 2, while one patient expired in group treating with statins (P‑value&gt;0.05).Discussion: We did not find statins administration to play any role in stroke recovery and consequent long‑term prognosis. More researches with larger samples are needed to establish the possible favorable outcome of&nbsp; statins when administered in cerebrovascular diseases.Keywords: Ischemic stroke, lovastatin, stroke prognosis, statins</Abstract>
</Article>
</ArticleSet>