Effect of Vitamin D Supplementation on Weight Loss, Glycemic Indices, and Lipid Profle in Obese and Overweight Women: A Clinical Trial Study

Abstract

Introduction: Vitamin D (vit D) defciency has defned as a health problem worldwide. World Health Organization (WHO) has declared that obesity is an epidemic of the 21st century. Previous studies have shown that obesity may increase the risk of Vit D defciency. Furthermore, other studies
have demonstrated that vit D insuffciency was accompanied with higher risk of type 2 diabetes, cardiovascular diseases, hypertension, and obesity. The aim of this study was to survey the effect of vit D supplementation on weight loss among overweight and obese women aged 20–40 years in
Isfahan.

Methods: This double‑blind clinical trial was done on 50 overweight and obese women who were divided into two groups, in which one group received vit D supplements and the other group received placebo. Intervention group received vit D with dozes 50,000 IU/w for 6 weeks.
The levels of total cholesterol (TC), triglyceride (TG), low‑density lipoprotein cholesterol (LDL‑c), high‑density lipoprotein cholesterol (HDL‑c), fasting blood sugar (FBS), insulin (ins), homeostasis model assessment of ins resistance (IR), C‑reactive protein (CRP), height, weight (WT), waist
circumference (WC), hip circumference (HC), and blood pressure (BP) were measured before and after intervention.

Results: After using vit D supplementation for 6 weeks, WT, WC, and body mass index (BMI) were decreased signifcantly and serum vit D increased signifcantly compared to control group (P < 0.001). Other factors including TC, TG, LDL‑c, HDL‑c, FBS, CRP, ins, IR, and waist to hip ratio (WHR) did not change signifcantly (P > 0.05).

Conclusions: After 6 weeks of intervention, the means of WT, BMI, WC, and HC decreased signifcantly. Previous studies have shown that vit
D defciency was more prevalence in obese people and there was an inverse association among vit D with BMI and WC. The relationship between vit D and lipid profles such as glycemic indexes, anthropometric indexes, CRP, and BP is not clear and needs more study in the future.

Keywords: Blood pressure, cholesterol, high‑density lipoprotein, low‑density lipoprotein, triglyceride, Vitamin D supplementation, weight loss, glycemic indices