Is Coffee and Green Tea Consumption Related to Serum Levels of Adiponectin and Leptin?
Abstract
Coffee and green tea are two of most usual consumed beverages in the world which have several beneft components. Coffee and green tea have signifcantly inverse correlation with obesity, diabetes, and cardiovascular diseases. Adiponectin and leptin are the adipokines mostly secreted from adipose tissue and play the important roles on the status of chronic diseases. In the present study, we aimed to review the evidence about relationship between these beverages and adiponectin and leptin levels.
We searched in PubMed to January 2013 using several key words such as coffee, green tea, caffeine, leptin, adiponectin, and adipokines. Finally, most related articles were recruited in this regard. Several fndings suggested the positive association between coffee and adiponectin level. Different studies showed contradictory results regarding green tea and adiponectin level. However, most of them reported the positive role of green tea in adiponectin concentration. Fewer studies are conducted
about the association between these beverages and leptin, and their results are controversial. More longitudinal investigations should be conducted in this regard to declare these associations.
Keywords
Full Text:
PDFReferences
Rebello SA, Chen CH, Naidoo N, Xu W, Lee J, Chia KS, et al.
Coffee and tea consumption in relation to inflammation and
basal glucose metabolism in a multi‑ethnic Asian population: A
cross‑sectional study. Nutr J 2011;10:61.
Kempf K, Herder C, Erlund I, Kolb H, Martin S, Carstensen M,
et al. Effects of coffee consumption on subclinical inflammation
and other risk factors for type 2 diabetes: A clinical trial. Am J
Clin Nutr 2010;91:950‑7.
Yamashita K, Yatsuya H, Muramatsu T, Toyoshima H,
Murohara T, Tamakoshi K, et al. Association of coffee
consumption with serum adiponectin, leptin, inflammation and
metabolic markers in japanese workers: A cross‑sectional study.
Nutr Diabetes 2012;2:e33.
Basu A, Du M, Sanchez K, Leyva MJ, Betts NM, Blevins S,
et al. Green tea minimally affects biomarkers of inflammation
in obese subjects with metabolic syndrome. Nutrition
;27:206‑13.
Bruno RS, Dugan CE, Smyth JA, DiNatale DA, Koo SI. Green
tea extract protects leptin‑deficient, spontaneously obese mice
from hepatic steatosis and injury. J Nutr 2008;138:323‑31.
Cho SY, Park PJ, Shin HJ, Kim YK, Shin DW, Shin ES,
et al. (‑)‑catechin suppresses expression of kruppel‑like factor
and increases expression and secretion of adiponectin
protein in 3T3‑L1 cells. Am J Physiol Endocrinol Metab
;292:E1166‑72.
Williams CJ, Fargnoli JL, Hwang JJ, van Dam RM,
Blackburn GL, Hu FB, et al. Coffee consumption is associated
with higher plasma adiponectin concentrations in women with
or without type 2 diabetes: A prospective cohort study. Diabetes
Care 2008;31:504‑7.
Izadi V, Farabad E, Azadbakht L. Serum adiponectin level and
different kinds of cancer: A review of recent evidence. ISRN
Oncol 2012;2012:982769.
Cha MC, Jones PJ. Dietary fat type and energy restriction
interactively influence plasma leptin concentration in rats.
J Lipid Res 1998;39:1655‑60.
Kratz M, von Eckardstein A, Fobker M, Buyken A, Posny N,
Schulte H, et al. The impact of dietary fat composition on serum
leptin concentrations in healthy nonobese men and women.
J Clin Endocrinol Metab 2002;87:5008‑14.
Shearer J, Farah A, de Paulis T, Bracy DP, Pencek RR,
Graham TE, et al. Quinides of roasted coffee enhance insulin
action in conscious rats. J Nutr 2003;133:3529‑32.
Rodríguez‑Morán M, Guerrero‑Romero F. Oral magnesium
supplementation improves insulin sensitivity and metabolic
control in type 2 diabetic subjects: A randomized double‑blind
controlled trial. Diabetes Care 2003;26:1147‑52.
Clifford MN. Chlorogenic acid and other cinnamates–nature,
occurrence, dietary burden, absorption and metabolism. J Sci
Food Agric 2000;80:1033‑43.
Ruiz‑Crespo S, Trejo‑Gabriel‑Galan JM, Cavia‑Saiz M,
Muñiz P. Coffee component 3‑caffeoylquinic acid increases
antioxidant capacity but not polyphenol content in experimental
cerebral infarction. Neurochem Res 2012;37:1085‑90.
Tunnicliffe JM, Shearer J. Coffee, glucose homeostasis, and
insulin resistance: Physiological mechanisms and mediators.
Appl Physiol Nutr Metab 2008;33:1290‑300.
Hilpert KF, Kris‑Etherton PM, West SG. Lipid response to
a low‑fat diet with or without soy is modified by C‑reactive
protein status in moderately hypercholesterolemic adults. J Nutr
;135:1075‑9.
Malerba S, Galeone C, Pelucchi C, Turati F, Hashibe M,
La Vecchia C, et al. A meta‑analysis of coffee and tea
consumption and the risk of glioma in adults. Cancer Causes
Control 2013;24:267‑76.
Rodriguez de Sotillo DV, Hadley M. Chlorogenic acid modifies
plasma and liver concentrations of: Cholesterol, triacylglycerol,
and minerals in (fa/fa) zucker rats. J Nutr Biochem
;13:717‑26.
Johnston KL, Clifford MN, Morgan LM. Coffee acutely modifies
gastrointestinal hormone secretion and glucose tolerance in
humans: Glycemic effects of chlorogenic acid and caffeine. Am J
Clin Nutr 2003;78:728‑33.
Astrup A, Toubro S, Cannon S, Hein P, Breum L, Madsen J,
et al. Caffeine: A double‑blind, placebo‑controlled study of its
thermogenic, metabolic, and cardiovascular effects in healthy
volunteers. Am J Clin Nutr 1990;51:759‑67.
Westerterp‑Plantenga MS, Lejeune MP, Kovacs EM. Body
weight loss and weight maintenance in relation to habitual
caffeine intake and green tea supplementation. Obes Res
;13:1195‑204.
Cao C, Wang L, Lin X, Mamcarz M, Zhang C, Bai G, et al.
Caffeine synergizes with another coffee component to increase
plasma GCSF: Linkage to cognitive benefits in Alzheimer’s
mice. J Alzheimers Dis 2011;25:323‑35.
Greenberg JA, Geliebter A. Coffee, hunger, and peptide YY.
J Am Coll Nutr 2012;31:160‑6.
Arab L, Khan F, Lam H. Epidemiologic evidence of a
relationship between tea, coffee, or caffeine consumption and
cognitive decline. Adv Nutr 2013;4:115‑22.
Dórea JG, da Costa TH. Is coffee a functional food? Br J Nutr
;93:773‑82.
Tse SY. Cholinomimetic compound distinct from caffeine
contained in coffee. II: Muscarinic actions. J Pharm Sci
;81:449‑52.
Health Canada Food Program. Fact sheet—it’s your health:
Caffeine. Ottawa, Canada: Health Canada, 2006. Internet:
Available from: http://www.hcsc. gc.ca/food-aliment/dg/e_
caffeine.html. [Last accessed on 2006 Jul 26].
Greenberg JA, Boozer CN, Geliebter A. Coffee, diabetes, and
weight control. Am J Clin Nutr 2006;84:682‑93.
van Dam RM, Hu FB. Coffee consumption and risk of type 2
diabetes: A systematic review. JAMA 2005;294:97‑104.
Lancaster T, Muir J, Silagy C. The effects of coffee on serum
lipids and blood pressure in a UK population. J R Soc Med
;87:506‑7.
Lopez‑Garcia E, van Dam RM, Qi L, Hu FB. Coffee consumption
and markers of inflammation and endothelial dysfunction in
healthy and diabetic women. Am J Clin Nutr 2006;84:888‑93.
Kono S, Shinchi K, Imanishi K, Todoroki I, Hatsuse K. Coffee
and serum gamma‑glutamyltransferase: A study of self‑defense
officials in japan. Am J Epidemiol 1994;139:723‑7.
Kao YH, Hiipakka RA, Liao S. Modulation of endocrine
systems and food intake by green tea epigallocatechin gallate.
Endocrinology 2000;141:980‑7.
Broadhurst CL, Polansky MM, Anderson RA. Insulin‑like
biological activity of culinary and medicinal plant aqueous
extracts in vitro. J Agric Food Chem 2000;48:849‑52.
Wu CH, Lu FH, Chang CS, Chang TC, Wang RH, Chang CJ,
et al. Relationship among habitual tea consumption, percent
body fat, and body fat distribution. Obes Res 2003;11:1088‑95.
Imai K, Nakachi K. Cross sectional study of effects of
drinking green tea on cardiovascular and liver diseases. BMJ
;310:693‑6.
Larsson SC, Männistö S, Virtanen MJ, Kontto J, Albanes D,
Virtamo J, et al. Coffee and tea consumption and risk of stroke
subtypes in male smokers. Stroke 2008;39:1681‑7.
Izadi V, Farabad E, Azadbakht L. Epidemiologic evidence
on serum adiponectin level and lipid profile. Int J Prev Med
;4:133‑40.
Azadbakht L, Esmaillzadeh A. Red meat intake is associated
with metabolic syndrome and the plasma C‑reactive protein
concentration in women. J Nutr 2009;139:335‑9.
Calle EE, Kaaks R. Overweight, obesity and cancer:
Epidemiological evidence and proposed mechanisms. Nat Rev
Cancer 2004;4:579‑91.
Kratz M, Swarbrick MM, Callahan HS, Matthys CC, Havel PJ,
Weigle DS, et al. Effect of dietary n‑3 polyunsaturated fatty
acids on plasma total and high‑molecular‑weight adiponectin
concentrations in overweight to moderately obese men and
women. Am J Clin Nutr 2008;87:347‑53.
Fargnoli JL, Fung TT, Olenczuk DM, Chamberland JP, Hu FB,
Mantzoros CS, et al. Adherence to healthy eating patterns is
associated with higher circulating total and high‑molecular‑weight
adiponectin and lower resistin concentrations in women from the
nurses’ health study. Am J Clin Nutr 2008;88:1213‑24.
Roberts CK, Berger JJ, Barnard RJ. Long‑term effects of diet
on leptin, energy intake, and activity in a model of diet‑induced
obesity. J Appl Physiol (1985) 2002;93:887‑93.
Weigle DS, Cummings DE, Newby PD, Breen PA, Frayo RS,
Matthys CC, et al. Roles of leptin and ghrelin in the loss of
body weight caused by a low fat, high carbohydrate diet. J Clin
Endocrinol Metab 2003;88:1577‑86.
Imatoh T, Tanihara S, Miyazaki M, Momose Y, Uryu Y,
Une H. Coffee consumption but not green tea consumption is
associated with adiponectin levels in Japanese Male. Eur J Nutr
;50:279‑89.
Lagiou P, Signorello LB, Mantzoros CS, Trichopoulos D,
Hsieh CC, Trichopoulou A, et al. Hormonal, lifestyle, and
dietary factors in relation to leptin among elderly men. Ann Nutr
Metab 1999;43:23‑9.
Hongu N, Sachan DS. Caffeine, carnitine and choline
supplementation of rats decreases body fat and serum leptin
concentration as does exercise. J Nutr 2000;130:152‑7.
Sone T, Kuriyama S, Nakaya N, Hozawa A, Shimazu T,
Nomura K, et al. Randomized controlled trial for an effect of
catechin‑enriched green tea consumption on adiponectin and
cardiovascular disease risk factors. Food Nutr Res 2011;55.
Doi: 10.3402/fnr.v55i0.8326.
Tunnicliffe JM, Shearer J: Coffee, glucose homeostasis, and
insulin resistance: physiological mechanisms and mediators.
Appl Physiol Nutr Metab 2008;33:1290-300.
Esmaillzadeh A, Kimiagar M, Mehrabi Y, Azadbakht L, Hu FB,
Willett WC, et al. Fruit and vegetable intakes, C‑reactive protein,
and the metabolic syndrome. Am J Clin Nutr 2006;84:1489‑97.
Esmaillzadeh A, Azadbakht L. Legume consumption is inversely
associated with serum concentrations of adhesion molecules
and inflammatory biomarkers among iranian women. J Nutr
;142:334‑9.
Azadbakht L, Haghighatdoost F, Karimi G, Esmaillzadeh A.
Effect of consuming salad and yogurt as preload on body weight
management and cardiovascular risk factors: A randomized
clinical trial. Int J Food Sci Nutr 2013;64:392‑9.
Miraghajani MS, Esmaillzadeh A, Najafabadi MM, Mirlohi M,
Azadbakht L. Soy milk consumption, inflammation, coagulation,
and oxidative stress among type 2 diabetic patients with
nephropathy. Diabetes Care 2012;35:1981‑5.
Ndumele CE, Pradhan AD, Ridker PM. Interrelationships
between inflammation, C‑reactive protein, and insulin resistance.
J Cardiometab Syndr 2006;1:190‑6.
Hukshorn CJ, Lindeman JH, Toet KH, Saris WH, Eilers PH,
Westerterp‑Plantenga MS, et al. Leptin and the proinflammatory
state associated with human obesity. J Clin Endocrinol Metab
;89:1773‑8.
Sun H, Zhang Y, Gao P, Li Q, Sun Y, Zhang J, et al. Adiponectin
reduces C‑reactive protein expression and downregulates STAT3
phosphorylation induced by IL‑6 in HepG2 cells. Mol Cell
Biochem 2011;347:183‑9.
Gressner OA, Lahme B, Rehbein K, Siluschek M, Weiskirchen R, Gressner AM, et al. Pharmacological application
of caffeine inhibits TGF‑beta‑stimulated connective tissue
growth factor expression in hepatocytes via PPARgamma and
SMAD2/3‑dependent pathways. J Hepatol 2008;49:758‑67.
Astrup A, Breum L, Toubro S, Hein P, Quaade F. The effect
and safety of an ephedrine/caffeine compound compared to
ephedrine, caffeine and placebo in obese subjects on an energy
restricted diet. A double blind trial. Int J Obes Relat Metab
Disord 1992;16:269‑77.
Dulloo AG, Geissler CA, Horton T, Collins A, Miller DS. Normal
caffeine consumption: Influence on thermogenesis and daily
energy expenditure in lean and postobese human volunteers. Am
J Clin Nutr 1989;49:44‑50.
Kotani K, Fujiwara S, Hamada T, Tsuzaki K, Sakane N. Coffee
consumption is associated with higher plasma adiponectin
concentrations in women with or without type 2 diabetes:
Response to Williams et al. Diabetes Care 2008;31:e46.
Kao YH, Chang HH, Lee MJ, Chen CL. Tea, obesity, and
diabetes. Mol Nutr Food Res 2006;50:188‑210.
Moon HS, Lee HG, Choi YJ, Kim TG, Cho CS. Proposed
mechanisms of (−)‑epigallocatechin‑3‑gallate for anti‑obesity.
Chem Biol Interact 2007;167:85‑98.
Bahceci M, Gokalp D, Bahceci S, Tuzcu A, Atmaca S, Arikan S,
et al. The correlation between adiposity and adiponectin, tumor
necrosis factor alpha, interleukin‑6 and high sensitivity C‑reactive
protein levels. Is adipocyte size associated with inflammation in
adults? J Endocrinol Invest 2007;30:210‑4.