<ArticleSet>
<Article>
<Journal>
<PublisherName></PublisherName>
<JournalTitle>International Journal of Preventive Medicine</JournalTitle>
<Issn>2008-7802</Issn>
<Volume>3</Volume>
<Issue>5</Issue>
<PubDate>
<Year>2011</Year>
<Month>07</Month>
<Day>12</Day>
</PubDate>
</Journal>
<ArticleTitle>25‑Hydroxyvitamin D Concentrations in Patients with Optic Neuritis as a Clinically Isolated Syndrome and Healthy Controls</ArticleTitle>
<FirstPage>233</FirstPage>
<LastPage>233</LastPage>
<Language>EN</Language>
<AuthorList>
<Author>
<FirstName>Masoud</FirstName>
<LastName>Etemadifar</LastName>
</Author>
<Author>
<FirstName>Seyed-Hossein</FirstName>
<LastName>Abtahi</LastName>
<Affiliation>Isfahan Eye Research Center (IERC), Ophthalmology Ward, Feiz Hospital, Isfahan University of Medical Sciences, Isfahan, Iran. shf.abtahi@yahoo.com</Affiliation>
</Author>
<Author>
<FirstName>Hassan</FirstName>
<LastName>Razmjoo</LastName>
</Author>
<Author>
<FirstName>Mohammad-Ali</FirstName>
<LastName>Abtahi</LastName>
</Author>
<Author>
<FirstName>Ali-Reza</FirstName>
<LastName>Dehghani</LastName>
</Author>
<Author>
<FirstName>Mehri</FirstName>
<LastName>Salari</LastName>
</Author>
<Author>
<FirstName>Amir-Hadi</FirstName>
<LastName>Maghzi</LastName>
</Author>
<Author>
<FirstName>Mojtaba</FirstName>
<LastName>Akbari</LastName>
</Author>
</AuthorList>
<History>
<PubDate>
<Year>2011</Year>
<Month>06</Month>
<Day>27</Day>
</PubDate>
<PubDate>
<Year>2011</Year>
<Month>07</Month>
<Day>08</Day>
</PubDate>
<PubDate>
<Year>2011</Year>
<Month>07</Month>
<Day>06</Day>
</PubDate>
</History>
<Abstract>Objectives: The onset of multiple sclerosis in the majority of the cases occurs as a clinically isolated syndrome (CIS). We sought to assess serum levels of 25-hydroxyvitamin D (25-OHD) in CIS patients and healthy controls. Methods: In this cross-sectional study 40 patients (36 women and 4 men) with CIS manifesting as a single isolated optic neuritis and 40 Age- and sex-matched healthy controls (35 women and 5 men) were enrolled between late October 2010 and early March 2011. General vitamin D deficiency was defined as serum 25-OHD levels of lower than 20 ng/ml and was classified as mild (15 &lt; 25-OHD &lt;20 ng/ml), moderate (8 &lt; 25-OHD &lt;15 ng/ml), and severe (25- OHD &lt;8 ng/ml). Results: We found no difference in the median interquartile range [IQR] between CIS patients and controls (17.95 [10.40- 29.13] vs. 17.00 [12.25-31.00]; P=0.57). However, when stratified by the levels of deficiency, among CIS patients a significantly higher proportion had severe vitamin D deficiency in comparison to healthy controls (20% vs. 2.5%; P=0.034). Nevertheless, the frequency of general (62.5% vs. 60%, P=0.82), mild (25% vs. 30%, P=0.80), and moderate (17.5% vs. 27.5%, P=0.42) vitamin D deficiency were not different between the two groups. Conclusions: Our findings do not indicate any significant difference of serum 25-OHD between CIS patients and healthy controls. However, in our series severe vitamin D deficiency was more frequent among CIS patients. Keywords: 25-Hydroxyvitamin D, Vitamin D deficiency, optic neuritis, multiple sclerosis, risk factor, prevention, Isfahan, Iran</Abstract>
</Article>
</ArticleSet>