The Effects of Curcumin Supplementation on Muscle Damage, Oxidative Stress, and Inflammatory Markers in Healthy Females with Moderate Physical Activity: A Randomized, Double‑Blind, Placebo‑Controlled Clinical Trial
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Simioni C, Zauli G, Martelli AM, Vitale M, Sacchetti G,
Gonelli A, et al. Oxidative stress: Role of physical exercise and
antioxidant nutraceuticals in adulthood and aging. Oncotarget
;9:17181‑98.
Crespo CJ, Palmieri MRG, Perdomo RP, Mcgee DL, Smit E,
Sempos CT, et al. The relationship of physical activity and body
weight with all‑cause mortality: Results from the Puerto Rico
Heart Health Program. Ann Epidemiol 2002;12:543‑52.
Warburton DE, Nicol CW, Bredin SS. Health benefits of physical
activity: The evidence. CMAJ 2006;174:801‑9.
Strobel NA, Peake JM, Matsumoto A, Marsh SA, Coombes JS,
Wadley GD. Antioxidant supplementation reduces skeletal
muscle mitochondrial biogenesis. Med Sci Sports Exerc
;43:1017‑24.
Reuter S, Gupta SC, Chaturvedi MM, Aggarwal BB. Oxidative
stress, inflammation, and cancer: How are they linked? Free
Radic Biol Med 2010;49:1603‑16.
Alaranta A, Alaranta H, Helenius I. Use of prescription drugs in
athletes. Sports Med 2008;38:449‑63.
Warden SJ. Prophylactic use of NSAIDs by athletes:
A risk/benefit assessment. Phys Sportsmed 2010;38:132‑8.
Davis JM, Murphy EA, Carmichael MD. Effects of the dietary
flavonoid quercetin upon performance and health. Curr Sports
Med Rep 2009;8:206‑13.
Smith J, Luo Y. Studies on molecular mechanisms of Ginkgo
biloba extract. Appl Microbiol Biotechnol 2004;64:465‑72.
Prasad S, Gupta SC, Tyagi AK, Aggarwal BB. Curcumin, a
component of golden spice: From bedside to bench and back.
Biotechnol Adv 2014;32:1053‑64.
Menon VP, Sudheer AR. Antioxidant and anti‑inflammatory
properties of curcumin. The molecular targets and therapeutic
uses of curcumin in health and disease: Springer; 2007. p. 105‑25.
Hewlings SJ, Kalman DS. Curcumin: A review of its’ effects on
human health. Foods 2017;6:92.
Davis JM, Murphy EA, Carmichael MD, Zielinski MR,
Groschwitz CM, Brown AS, et al. Curcumin effects on
inflammation and performance recovery following eccentric
exercise‑induced muscle damage. Am J Physiol Regul Integr
Comp Physiol 2007;292:R2168‑73.
Gukovsky I, Reyes CN, Vaquero EC, Gukovskaya AS,
Pandol SJ. Curcumin ameliorates ethanol and nonethanol
experimental pancreatitis. Am J Physiol Gastrointest Liver
Physiol 2003;284:G85‑95.
Lim GP, Chu T, Yang F, Beech W, Frautschy SA, Cole GM. The
curry spice curcumin reduces oxidative damage and amyloid
pathology in an Alzheimer transgenic mouse. J Neurosci
;21:8370‑7.
Sahin K, Pala R, Tuzcu M, Ozdemir O, Orhan C, Sahin N, et al.
Curcumin prevents muscle damage by regulating NF‑κB and
Nrf2 pathways and improves performance: An in vivo model.
J Inflamm Res 2016;9:147‑54.
Mohammadi S, Karimzadeh Bardei L, Hojati V, Ghorbani AG,
Nabiuni M. Anti‑Inflammatory effects of curcumin on insulin
resistance index, levels of Interleukin‑6, C‑reactive protein, and
liver histology in polycystic ovary syndrome‑induced rats. Cell J
;19:425‑33.
Sciberras JN, Galloway SD, Fenech A, Grech G, Farrugia C,
Duca D, et al. The effect of turmeric (Curcumin) supplementation
on cytokine and inflammatory marker responses following
hours of endurance cycling. J Int Soc Sports Nutr 2015;12:5.
Khera A, McGuire DK, Murphy SA, Stanek HG, Das SR,
Vongpatanasin W, et al. Race and gender differences in
C‑reactive protein levels. J Am Coll Cardiol 2005;46:464‑9.
McFarlin BK, Venable AS, Henning AL, Sampson JN, Pennel K,
Vingren JL, et al. Reduced inflammatory and muscle damage
biomarkers following oral supplementation with bioavailable
curcumin. BBA Clin 2016;5:72‑8.
Hosseini‑Esfahani F, Asghari G, Mirmiran P, Jalali Farahani S,
Azizi F. Reproducibility and relative validity of food group
intake in a food frequency questionnaire developed for the
Tehran Lipid and Glucose Study. Razi J Med Sci 2010;17:41‑55.
Most MM. Estimated phytochemical content of the dietary
approaches to stop hypertension (DASH) diet is higher than in
the control study diet. J Am Diet Assoc 2004;104:1725‑7.
McArdle W, Katch FI, Pechar GS, Jacobson L, Ruck S.
Reliability and interrelationships between maximal oxygen
intake, physical work capacity and step‑test scores in college
women. Med Sci Sports 1972;4:182‑6.
Benzie IF, Strain JJ. The ferric reducing ability of plasma (FRAP)
as a measure of “antioxidant power”: The FRAP assay. Anal
Biochem 1996;239:70‑6.
Rajaei Z, Hadjzadeh M‑A‑R, Nemati H, Hosseini M, Ahmadi M,
Shafiee S. Antihyperglycemic and antioxidant activity of
crocin in streptozotocin‑induced diabetic rats. J Med Food
;16:206‑10.
Tabrizi R, Vakili S, Akbari M, Mirhosseini N, Lankarani KB,
Rahimi M, et al. The effects of curcumin-containing supplements
on biomarkers of inflammation and oxidative stress: A systematic
review and meta-analysis of randomized controlled trials.
Phytother Res 2019;33:253‑62.
Panahi Y, Sahebkar A, Parvin S, Saadat A. A randomized
controlled trial on the anti‑inflammatory effects of curcumin
in patients with chronic sulphur mustard‑induced cutaneous
complications. Ann Clin Biochem 2012;49:580‑8.
Sahebkar A, Cicero AF, Simental‑Mendia LE, Aggarwal BB,
Gupta SC. Curcumin downregulates human tumor necrosis
factor‑α levels: A systematic review and meta‑analysis
ofrandomized controlled trials. Pharmacol Res 2016;107:234‑42.
Henrotin Y, Clutterbuck A, Allaway D, Lodwig E, Harris P,
Mathy‑Hartert M, et al. Biological actions of curcumin on
articular chondrocytes. Osteoarthritis Cartilage 2010;18:141‑9.
Hatcher H, Planalp R, Cho J, Torti F, Torti S. Curcumin: From
ancient medicine to current clinical trials. Cell Mol Life Sci
;65:1631‑52.
Tornatore L, Thotakura AK, Bennett J, Moretti M,
Franzoso G. The nuclear factor kappa B signaling pathway:
Integrating metabolism with inflammation. Trends Cell Bio
;22:557‑66.
Panahi Y, Khalili N, Sahebi E, Namazi S, Karimian MS,
Majeed M, et al. Antioxidant effects of curcuminoids in patients
with type 2 diabetes mellitus: A randomized controlled trial.
Inflammopharmacology 2017;25:25‑31.
Belcaro G, Cesarone M, Dugall M, Pellegrini L, Ledda A,
Grossi M, et al. Product‑evaluation registry of Meriva®, a
curcumin‑phosphatidylcholine complex, for the complementary
management of osteoarthritis. Panminerva Med 2010;52:55‑62.
Panahi Y, Alishiri GH, Parvin S, Sahebkar A. Mitigation of
systemic oxidative stress by curcuminoids in osteoarthritis:
Results of a randomized controlled trial. J Diet Supp
;13:209‑20.
Pingitore A, Lima GPP, Mastorci F, Quinones A, Iervasi G,
Vassalle C. Exercise and oxidative stress: Potential effects
of antioxidant dietary strategies in sports. Nutrition
;31:916‑22.
Banach M, Serban C, Aronow WS, Rysz J, Dragan S, Lerma EV,
et al. Lipid, blood pressure and kidney update 2013. Int Urol
Nephrol 2014;46:947‑61.
Di Pierro F, Bressan A, Ranaldi D, Rapacioli G, Giacomelli L,
Bertuccioli A. Potential role of bioavailable curcumin in weight loss
and omental adipose tissue decrease: Preliminary data of a randomized,
controlled trial in overweight people with metabolic syndrome.
Preliminary study. Eur Rev Med Pharmacol Sci 2015;19:4195‑202.
Qu X, Zhao S, Xu J, Dong L. Effects of curcumin on secretion
of adiponectin and interleukin‑6 in human adipose tissues: An
in vitro study. Zhong Xi Yi Jie He Xue Bao 2008;6:711‑5.
Hu GX, Lin H, Lian QQ, Zhou SH, Guo J, Zhou HY,
et al. Curcumin as a potent and selective inhibitor of
β‑hydroxysteroid dehydrogenase 1: Improving lipid profiles in
high‑fat‑diet‑treated rats. PloS One 2013;8:e49976.