Email this article 
The Effects of Curcumin Administration on Carotid Intima‑Media Thickness and Pulse Wave Velocity in Diabetic Hemodialysis Patients: A Randomized, Double‑Blinded, Placebo‑Controlled Trial
Abstract
Background: Prior studies have reported that curcumin is inversely associated with reduced markers of atherosclerosis risk, including carotid intima‑media thickness (CIMT). This study was designed to assess the effects of curcumin on CIMT and pulse wave velocity (PWV) in diabetic hemodialysis (HD) patients. Methods: This randomized, double‑blinded, placebo‑controlled trial was conducted on 39 diabetic HD patients. People were assigned to receive curcumin or placebo (starch) for 24 weeks. Individuals in the curcumin group (n = 26) received 80 mg/day. CIMT and PWV levels were taken at baseline and after 24 weeks of intervention. Results: After 24 weeks of intervention, curcumin intake did not affect mean levels of left (P = 0.83) and right (P = 0.47) CIMT and maximum levels of left (P = 0.84) and right (P = 0.11) CIMT, and PWV (P = 0.12) compared to the placebo. Furthermore, within‑group difference demonstrated a significant reduction in mean levels of PWV (P = 0.01) in the curcumin group. We did not observe any significant change in C‑reactive protein (CRP) concentrations after curcumin intake (P = 0.69). Conclusions: Curcumin intake did not affect mean levels of left and right CIMT and maximum levels of left and right CIMT, PWV, and CRP levels compared to the placebo. Additionally, within‑group difference demonstrated a significant reduction in mean levels of PWV in the curcumin group. This trial was registered at www.irct.ir as http://www.irct.ir: IRCT20200527047584N1.
International Journal of Preventive Medicine 15():3, January 2024. | DOI: 10.4103/ijpvm.ijpvm_55_22
Corresponding Author: Dr. Hamid R. Talari
E‑mail: talari2008hr@yahoo.com
You can also search for this author in: PubMed Google Scholar
Keywords
Full Text:
PDFReferences
Bahie A, El‑Said G, Abd El Wahab AM. Relation between
carotid intimal medial thickness and left ventricular mass and left
ventricular mass indices in maintenance hemodialysis patients.
Ther Apher Dial 2022;26:387‑97.
Navarro JF, Mora C, Muros M, García‑Idoate G. Effects of
atorvastatin on lipid profile and non‑traditional cardiovascular
risk factors in diabetic patients on hemodialysis. Nephron Clin
Pract 2003;95:c128‑35.
Sanada H, Higashi Y, Goto C, Chayama K,
Yoshizumi M, Sueda T. Vascular function in patients with
lower extremity peripheral arterial disease: A comparison
of functions in upper and lower extremities. Atherosclerosis
;178:179‑85.
Esper RJ, Nordaby RA, Vilariño JO, Paragano A,
Cacharrón JL, Machado RA. Endothelial dysfunction:
A comprehensive appraisal. Cardiovasc Diabetol 2006;5:4. doi:
1186/1475‑2840‑5‑4.
Wolf M, Weir MR, Kopyt N, Mannon RB, Von Visger J,
Deng H, et al. A prospective cohort study of mineral
metabolism after kidney transplantation. Transplantation
;100:184‑93.
Kapakos G, Youreva V, Srivastava AK. Cardiovascular protection
by curcumin: molecular aspects. Indian J Biochem Biophys
;49:306‑15.
Sveen KA, Dahl‑Jørgensen K, Stensaeth KH, Angel K,
Seljeflot I, Sell DR, et al. Glucosepane and oxidative markers in
skin collagen correlate with intima media thickness and arterial
stiffness in long‑term type 1 diabetes. J Diabetes Complications
;29:407‑12.
Alidadi M, Sahebkar A, Eslami S, Vakilian F, Jarahi L,
Alinezhad‑Namaghi M, et al. The effect of curcumin
supplementation on pulse wave velocity in patients
with metabolic syndrome: A randomized, double‑blind,
placebo‑controlled trial. Adv Exp Med Biol 2021;1308:1‑11.
Nakmareong S, Kukongviriyapan U, Pakdeechote P,
Kukongviriyapan V, Kongyingyoes B, Donpunha W, et al.
Tetrahydrocurcumin alleviates hypertension, aortic stiffening and
oxidative stress in rats with nitric oxide deficiency. Hypertens
Res 2012;35:418‑25.
Majithiya JB, Balaraman R. Time‑dependent changes in
antioxidant enzymes and vascular reactivity of aorta in
streptozotocin‑induced diabetic rats treated with curcumin.
J Cardiovasc Pharmacol 2005;46:697‑705.
Fleenor BS, Sindler AL, Marvi NK, Howell KL, Zigler ML,
Yoshizawa M, et al. Curcumin ameliorates arterial dysfunction
and oxidative stress with aging. Exp Gerontol 2013;48:269‑76.
Santos‑Parker JR, Strahler TR, Bassett CJ, Bispham NZ,
Chonchol MB, Seals DR. Curcumin supplementation improves
vascular endothelial function in healthy middle‑aged and older
adults by increasing nitric oxide bioavailability and reducing
oxidative stress. Aging 2017;9:187‑208.
Murugan P, Pari L. Influence of tetrahydrocurcumin on
hepatic and renal functional markers and protein levels in
experimental type 2 diabetic rats. Basic Clin Pharmacol Toxicol
;101:241‑5.
Ghosh SS, Massey HD, Krieg R, Fazelbhoy ZA, Ghosh S,
Sica DA, et al. Curcumin ameliorates renal failure in 5/6
nephrectomized rats: Role of inflammation. Am J Physiol Renal
Physiol 2009;296:F1146‑57.
Fallah M, Askari G, Soleimani A, Feizi A, Asemi Z. Clinical trial
of the effects of coenzyme q10 supplementation on biomarkers
of inflammation and oxidative stress in diabetic hemodialysis
patients. Int J Prev Med 2019;10:12.
Talari HR, Zakizade M, Soleimani A, Bahmani F, Ghaderi A,
Mirhosseini N, et al. Effects of magnesium supplementation
on carotid intima‑media thickness and metabolic profiles in
diabetic haemodialysis patients: A randomised, double‑blind,
placebo‑controlled trial. Br J Nutr 2019;121:809‑17.
Soleimani A, Motamedzadeh A, Zarrati Mojarrad M, Bahmani F,
Amirani E, Ostadmohammadi V, et al. The effects of synbiotic
supplementation on metabolic status in diabetic patients undergoing
hemodialysis: A randomized, double‑blinded, placebo‑controlled
trial. Probiotics Antimicrob Proteins 2019;11:1248‑56.
Hallajzadeh J, Milajerdi A, Kolahdooz F, Amirani E, Mirzaei H,
Asemi Z. The effects of curcumin supplementation on endothelial
function: A systematic review and meta‑analysis of randomized
controlled trials. Phytother Res 2019;33:2989‑95.
Changal KH, Khan MS, Bashir R, Sheikh MA. Curcumin
preparations can improve flow‑mediated dilation and endothelial
function: A meta‑analysis. Complement Med Res 2020;27:272‑81.
Barber‑Chamoux N, Milenkovic D, Verny MA, Habauzit V,
Pereira B, Lambert C, et al. Substantial variability across
individuals in the vascular and nutrigenomic response to an acute
intake of curcumin: A randomized controlled trial. Mol Nutr
Food Res 2018;62. doi: 10.1002/mnfr. 201700418.
Campbell MS, Berrones AJ, Krishnakumar I, Charnigo RJ,
Westgate PM, Fleenor BS. Responsiveness to curcumin
intervention is associated with reduced aortic stiffness in
young, obese men with higher initial stiffness. J Funct Foods
;29:154‑60.
Sugawara J, Akazawa N, Miyaki A, Choi Y, Tanabe Y, Imai T,
et al. Effect of endurance exercise training and curcumin intake
on central arterial hemodynamics in postmenopausal women:
pilot study. Am J Hypertens 2012;25:651‑6.
White CM, Pasupuleti V, Roman YM, Li Y, Hernandez AV. Oral
turmeric/curcumin effects on inflammatory markers in chronic
inflammatory diseases: A systematic review and meta‑analysis of
randomized controlled trials. Pharmacol Res 2019;146:104280.
doi: 10.1016/j.phrs. 2019.104280.
Tabrizi R, Vakili S, Akbari M, Mirhosseini N, Lankarani KB,
Rahimi M, et al. The effects of curcumin‑containing supplements
on biomarkers of inflammation and oxidative stress: A systematic
review and meta‑analysis of randomized controlled trials.
Phytother Res 2019;33:253‑62.
Samadian F, Dalili N, Poor‑Reza Gholi F, Fattah M, Malih N,
Nafar M, et al. Evaluation of curcumin’s effect on inflammation
in hemodialysis patients. Clin Nutr ESPEN 2017;22:19‑23.
Jamilian M, Foroozanfard F, Kavossian E, Aghadavod E,
Shafabakhsh R, Hoseini A, et al. Effects of curcumin on
body weight, glycemic control and serum lipids in women
with polycystic ovary syndrome: A randomized, double‑blind,
placebo‑controlled trial. Clin Nutr ESPEN 2020;36:128‑33.
Panahi Y, Ghanei M, Bashiri S, Hajihashemi A, Sahebkar A.
Short‑term curcuminoid supplementation for chronic pulmonary
complications due to sulfur mustard intoxication: Positive results
of a randomized double‑blind placebo‑controlled trial. Drug Res
;65:567‑73.