Dynamics of Dairy Product Consumption, Confounding Factors, and Their Influence on the Risk of Type 2 Diabetes

Sanjeev K. Gautam, Bimlesh Kumar, Prashant Kumbhar, Narendra K. Pandey

Abstract


It has long been debated whether or not dairy consumption increases the risk of type 2 diabetes (T2D). This link has been assessed by a large number of case‑control studies, prospective cohort studies, systematic reviews, and meta‑analyses. The majority of their studies demonstrated an inverse relationship between the risk of T2D and dairy consumption. It is yet unclear how dairy products specifically contribute to metabolic diseases like type 2 diabetes. However, a surprising number of studies have indicated either no association or a positive correlation between the development of type 2 diabetes and certain dairy products. The objective of this narrative review is to collate research findings from diverse geographical contexts, exploring the impact of dairy product consumption on the incidence and risk of Type 2 diabetes (T2D). This review includes studies that addressed this research issue and were released between the years 2000 and 2023. This will help the public draw logical inferences and validate the body of recent research. To shed light on this matter, the writers conduct a comprehensive search of electronic scientific databases such as PubMed, Scopus, and Web of Science. Thus, this review emphasizes the connection between the usage of different dairy products and the risk of T2D. After controlling for confounding variables, this review indicates that the relationship between the incidence of type 2 diabetes and consumption of dairy products is context‑dependent. In conclusion, not all dairy products help to prevent type 2 diabetes. There is no association between most other dairy products and T2D, while in some cases benefits of yogurt and other low‑fat dairy products have been reported.

Keywords


Confounders; dairy consumption; dietary impact; milkfat; nutrition

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References


National Diabetes Statistics Report. Cdc.gov. 2023. Available from: https://www.cdc.gov/diabetes/data/statisticsreport/index. html. [Last accessed on 2023 Nov 29].

Slurink IAL, den Braver NR, Rutters F, Kupper N, Smeets T, Elders PJM, et al. Dairy product consumption and incident prediabetes in Dutch middleaged adults: The Hoorn studies prospective cohort. Eur J Nutr 2021;61:18396.

Slurink IAL, Voortman T, OchoaRosales C, Ahmadizar F, Kavousi M, Kupper N, et al. Dairy product consumption in relation to incident prediabetes and longitudinal insulin resistance in the Rotterdam study. Nutrients 2022;14:415. doi: 10.3390/nu14030415.

Zemel MB. Proposed role of calcium and dairy food components in weight management and metabolic health. Phys Sportsmed. 2009;37:2939. doi: 10.3810/psm.2009.06.1707.

Rice BH, Cifelli CJ, Pikosky MA, Miller GD. Dairy components and risk factors for cardiometabolic syndrome: Recent evidence and opportunities for future research. Adv Nutr 2011;2:396407.

Centre National Interprofessionnel de l’Economie Laitière (CNIEL)/International Dairy Federation (IDF), Food and Agriculture Organization (FAO) Food Outlook, PRB. Per capita milk consumption from 2006 to 2019. Paper presented at the Annual National Workshop for Dairy Economists and Policy Analysts, Boston, MA, 2019.

Smiley JD. Dairy products may protect against type 2 diabetes, but red and processed meat raise risk. Medical News Today. 2022. Available from: https://www.medicalnewstoday.com/articles/ dairyproductsmayprotectagainsttype2diabetesbutredand processedmeatraiserisk [Last accessed on 2023 Jun 28].

Yeboah J, Bertoni AG, Herrington DM, Post WS, Burke GL. Impaired fasting glucose and the risk of incident diabetes mellitus and cardiovascular events in an adult population: MESA (MultiEthnic Study of Atherosclerosis). J Am Coll Cardiol 2011;58:1406.

Cai X, Zhang Y, Li M, Wu JH, Mai L, Li J, et al. Association between prediabetes and risk of all cause mortality and cardiovascular disease: Updated metaanalysis. BMJ 2020;370:m2297. doi: 10.1136/bmj.m2297.

Caspuk.net. Available from: https://caspuk.net/checklists/ caspcohortstudieschecklistfillable.pdf. [Last accessed on 2024 Mar 13].

Slurink IA, Chen L, Magliano DJ, Kupper N, Smeets T, SoedamahMuthu SS. Dairy product consumption and incident prediabetes in the Australian diabetes, obesity, and lifestyle study with 12 years of followup. J Nutr 2023;153:174252.

Vinke PC, Corpeleijn E, Dekker LH, Jacobs DR, Navis G, Kromhout D. Development of the foodbased lifelines diet score (LLDS) and its application in 129,369 lifelines participants. Eur J Clin Nutr 2018;72:11119.

Slurink IA, Corpeleijn E, Bakker SJ, Jongerling J, Kupper N, Smeets T, SoedamahMuthu SS. Dairy consumption and incident prediabetes: Prospective associations and network models in the large populationbased Lifelines Study. Am J Clin Nutr 2023118:107790.

Hruby A, Ma J, Rogers G, Meigs JB, Jacques PF. Associations of dairy intake with incident prediabetes or diabetes in middle aged adults vary by both dairy type and glycemic status. J Nutr 2017;147:176475.

Sluijs I, Forouhi NG, Beulens JWJ, van der Schouw YT, Agnoli C, Arriola L, et al. The amount and type of dairy product intake and incident type 2 diabetes: Results from the EPIC InterAct study. Am J Clin Nutr 2012;96:38290.

Yuzbashian E, Asghari G, Mirmiran P, Chan CB, Azizi F. Correction to: Changes in dairy product consumption and subsequent type 2 diabetes among individuals with prediabetes: Tehran lipid and glucose study. Nutr J 2021;20:95.

Ardisson Korat AV, Li Y, Sacks F, Rosner B, Willett WC, Hu FB, et al. Dairy fat intake and risk of type 2 diabetes in 3 cohorts of US men and women. Am J Clin Nutr 2019;110:1192200.

DrouinChartier JP, Li Y, Ardisson Korat AV, Ding M, Lamarche B, Manson JE, et al. Changes in dairy product consumption and risk of type 2 diabetes: Results from 3 large prospective cohorts of US men and women. Am J Clin Nutr 2019;110:120112.

Kummer K, Jensen PN, Kratz M, Lemaitre RN, Howard BV, Cole SA, et al. Fullfat dairy food intake is associated with a lower risk of incident diabetes among American Indians with low total dairy food intake. J Nutr 2019;149:123844.

Feng Y, Zhao Y, Liu J, Huang Z, Yang X, Qin P, et al. Consumption of dairy products and the risk of overweight or obesity, hypertension, and type 2 diabetes mellitus: A dose response metaanalysis and systematic review of cohort Studies. Adv Nutr 2022;13:216579.

Aune D, Norat T, Romundstad P, Vatten LJ. Dairy products and the risk of type 2 diabetes: A systematic review and dose response metaanalysis of cohort studies. Am J Clin Nutr 2013;98:106683.

Yang Y, Na X, Xi Y, Xi M, Yang H, Li Z, et al. Association between dairy consumption and the risk of diabetes: A prospective cohort study from the China health and nutrition survey. Front Nutr 2022;9:997636. doi: 10.3389/fnut. 2022.997636.

Villegas R, Gao YT, Dai Q, Yang G, Cai H, Li H, et al. Dietary calcium and magnesium intakes and the risk of type 2 diabetes: The Shanghai women’s health study. Am J Clin Nutr 2009;89:105967.

Liu S, Choi HK, Ford E, Song Y, Klevak A, Buring JE, et al. A prospective study of dairy intake and the risk of type 2 diabetes in women. Diabetes Care 2006;29:157984.

Gil Á, Ortega RM. Introduction and executive summary of the supplement, role of milk and dairy products in health and prevention of noncommunicable chronic diseases: A series of systematic reviews. Adv Nutr 2019;10(Suppl 2):S6773.

Gudi SK. Eating speed and the risk of type 2 diabetes: Explorations based on realworld evidence. Ann Pediatr Endocrinol Metab 2020;25:803.

Aune D, Lau R, Chan DS, Vieira R, Greenwood DC, Kampman E, et al. Dairy products and colorectal cancer risk: A systematic review and metaanalysis of cohort studies. Ann Oncol 2012;23:3745.

CNIEL)/International Dairy Federation (IDF), Food and Agriculture Organization (FAO) Food Outlook, PRB. Per capita milk consumption from 20062019. Available from: https://www. filierelaitiere.fr/en/cniel [Last accessed on 2023 Jul 19].

Ratnayake WMN. Concerns about the use of 15:0, 17:0, and trans 16:1n7 as biomarkers of dairy fat intake in recent observational studies that suggest beneficial effects of dairy food on incidence of diabetes and stroke. Am J Clin Nutr 2015;101:1102 3.