<ArticleSet>
<Article>
<Journal>
<PublisherName></PublisherName>
<JournalTitle>International Journal of Preventive Medicine</JournalTitle>
<Issn>2008-7802</Issn>
<Volume>3</Volume>
<Issue>2</Issue>
<PubDate>
<Year>2011</Year>
<Month>08</Month>
<Day>17</Day>
</PubDate>
</Journal>
<ArticleTitle>The Role of Maternal Thyroid Stimulating Hormone Receptor Blocking Antibodies in the Etiology of Congenital Hypothyroidism in Isfahan, Iran</ArticleTitle>
<FirstPage>305</FirstPage>
<LastPage>305</LastPage>
<AuthorList>
<Author>
<FirstName>Mahin</FirstName>
<LastName>Hashemipour</LastName>
</Author>
<Author>
<FirstName>Shima</FirstName>
<LastName>Salehi Abari</LastName>
<Affiliation>Department of Pediatrics, Faculty of Medicine, and Child Health Promotion Research Center, IUMS, Isfahan. shimasalehiabari@yahoo.com</Affiliation>
</Author>
<Author>
<FirstName>Shaghayegh</FirstName>
<LastName>Haghjooy Javanmard</LastName>
</Author>
<Author>
<FirstName>Nafise</FirstName>
<LastName>Esmail</LastName>
</Author>
<Author>
<FirstName>Silva</FirstName>
<LastName>Hovsepian</LastName>
</Author>
<Author>
<FirstName>Masoud</FirstName>
<LastName>Amini</LastName>
</Author>
<Author>
<FirstName>Roya</FirstName>
<LastName>Kelishadi</LastName>
</Author>
<Author>
<FirstName>Akbar</FirstName>
<LastName>Hasanzadeh</LastName>
</Author>
<Author>
<FirstName>Mehrdad</FirstName>
<LastName>Mirouliaei</LastName>
</Author>
</AuthorList>
<History>
<PubDate>
<Year>2011</Year>
<Month>08</Month>
<Day>13</Day>
</PubDate>
<PubDate>
<Year>2011</Year>
<Month>08</Month>
<Day>13</Day>
</PubDate>
</History>
<Abstract>Background: Considering the role of maternal thyroid stimulatinghormone (TSH) receptor blocking antibody (TRAb) in the etiology ofcongenital hypothyroidism (CH), this study aimed to determine TRAbamong patients with CH in Isfahan, Iran.Methods: In this case&ndash;control study, patients with CH and their motherswere compared with a group of healthy neonates and their mothers.Venous blood samples were obtained for measurement of TRAb usingenzyme-linked immunosorbent assay (ELISA) method among mothersand their neonates. TSH of mothers was also determined.Results: The case group consisted of 65 patients with CH and theirmothers; controls were 148 healthy neonates and their mothers. Theprevalence of positive TRAb in patients with CH and their motherswas higher than in the control group (81.5% vs. 1.3% in mothers and80% vs. 0% in neonates, respectively, P&lt;0.05). The relationship betweenthe TRAb and occurrence of CH was significant (P&lt;0.05), whereas thecorresponding figure was not significant for TRAb and the level ofmaternal and neonatal TSH in case and control groups (P&gt;0.05).Conclusion: It seems that autoimmunity has an important role inthe etiology of CH. Further studies are necessary to determine otherautoantibodies in CH patients.Keywords: Congenital hypothyroidism, etiology, thyroid stimulatinghormone receptor blocking, autoimmunity</Abstract>
</Article>
</ArticleSet>