<ArticleSet>
<Article>
<Journal>
<PublisherName></PublisherName>
<JournalTitle>International Journal of Preventive Medicine</JournalTitle>
<Issn>2008-7802</Issn>
<Volume>3</Volume>
<Issue>4</Issue>
<PubDate>
<Year>2012</Year>
<Month>03</Month>
<Day>27</Day>
</PubDate>
</Journal>
<ArticleTitle>Is Routine Duodenal Biopsy Necessary for the Detection of Celiac Disease in Patients Presenting with Iron Deficiency Anemia?</ArticleTitle>
<FirstPage>593</FirstPage>
<LastPage>593</LastPage>
<Language>EN</Language>
<AuthorList>
<Author>
<FirstName>Mohammad Hassan</FirstName>
<LastName>Emami</LastName>
</Author>
<Author>
<FirstName>Somayeh</FirstName>
<LastName>Karimi</LastName>
</Author>
<Author>
<FirstName>Soheila</FirstName>
<LastName>Kouhestani</LastName>
<Affiliation>. s_karimi@med.mui.ac.ir</Affiliation>
</Author>
</AuthorList>
<History>
<PubDate>
<Year>2012</Year>
<Month>03</Month>
<Day>27</Day>
</PubDate>
</History>
<Abstract>Backgrounds: Iron deficiency anemia (IDA) is one of the wellrecognized presentations of celiac disease (CD). According to thelack of data from our population in this regard, we determined the prevalence of CD in patients presenting with IDA to see if it is worthwhile to do a precise screening for CD in such patients.Methods: This cross-sectional study was conducted on patientsreferred with IDA to Poursina Hakim Gastroenterology Clinic, Isfahan (IRAN). All included patients underwent upper gastrointestinal endoscopy and duodenal biopsy. Histopathological changes were assessed according to the Marsh classification. Also, patients were evaluated for IgA anti-tissue transglutaminase (t-TG) antibody with enzyme-linked immunosorbent assay (ELISA) technique. CD was defined as having Marsh II or above histopathology or being seropositive with Marsh I histopathology and having a good response to gluten free diet (GFD).Results: During the study, 130 patients with the mean age of35.5&plusmn;13.7 (67.7% female [20.4% post-menopausal]) were undergone seropathological studies. According to&nbsp; histopathological study and a clinical response to GFD, 13 patients (10%) were ultimately diagnosed with CD. Nine patients (6.9%) were seropositive, from which, five patients (3.8%) were ultimately diagnosed as CD cases. IgA anti-tTG became negative in all of these patients after six months of GFD.Conclusion: CD should be considered in any adult patientpresenting with unexplained IDA, even if not accompanied withgastrointestinal symptoms. Routine duodenal biopsy performedduring diagnostic upper gastrointestinal endoscopy is worthwhilein order to investigate for CD as an underlying cause of IDA inadult patients.Keywords: Celiac disease, diagnosis, iron deficiency anemia</Abstract>
</Article>
</ArticleSet>