Preventive and Curative Effects of Ginger Extract Against Histopathologic Changes of Gentamicin‑Induced Tubular Toxicity in Rats

Hamid Nasri, Mehdi Nematbakhsh, Shamin Ghobadi, Roya Ansari, Najmeh Shahinfard, Mahmoud Rafieian-kopaei


 Background: Gentamicin (GM) is a commonly used aminoglycoside, however, renal toxicity has limited its usage. This study was designed to evaluate the curative and protective effects of Zingiber officinale (ginger) against gentamicin tubular toxicity in rats. The phenolic and flavonoid components and antioxidant activity of ginger were also evaluated.

Methods: In a preclinical study, 50 male Wistar rats were designated into 5 groups of 10 and treated as follows: Group I: vehicle. Group II: 200 mg/kg/d of ginger for 3 days then, GM (80 mg/kg) for 7 days. Group III: 200 mg/kg ginger orally for 3 days, then ginger plus GM for 7 days. Group IV: GM for 7 days. Group V: GM for 10 days. Group VI: GM for 7 days, then 200 mg/kg ginger orally for 10 days. At the end of the study, the animals were sacrificed and their kidneys were histologically evaluated.

Results: Ginger could prevent degeneration of the renal cells and reduce the severity of tubular damage caused by gentamicin. However, it could not regenerate the GM degeneration.

Conclusions: The results indicate that ginger is effective as a prophylaxis agent, but has not curative effect.

Keywords: Gentamicin, ginger, nephrotoxicity, tubular damage, zingiber officinale

Full Text: